Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5582
Title: Relationship between cardiopulmonary bypass flow rate and cerebral embolization in dogs
Authors: Sungurtekin, H.
Plöchl, W.
Cook, D.J.
Keywords: Cerebral blood flow
Cerebral emboli
Pump flow
animal experiment
animal tissue
arterial carbon dioxide tension
article
blood flow velocity
brain blood flow
brain embolism
brain tissue
cardiopulmonary bypass
dog
hemoglobin determination
mean arterial pressure
nonhuman
pathogenesis
priority journal
Animals
Blood Pressure
Cardiopulmonary Bypass
Coronary Circulation
Dogs
Fluorescent Dyes
Intracranial Embolism
Microspheres
Risk Assessment
Abstract: Background: Cerebral embolization is a primary cause of cardiac surgical neurologic morbidity. During cardiopulmonary bypass (CPB), there are well- defined periods of embolic risk. In theory, cerebral embolization might be reduced by an increase in pump flow during these periods. The purpose of this study was to determine the CPB flow-embolization relation in a canine model. Methods: Twenty mongrel dogs underwent CPB at 35°C with ?-stat management and a fentanyl-midazolam anesthetic. In each animal, CPB flow was adjusted to achieve a mean arterial pressure of 65-75 mmHg. During CPB, an embolic load of 1.2 x 103 67 µm fluorescent microspheres was injected into the arterial inflow line. Before and after embolization, cerebral blood flow was determined using 15-µm microspheres. Tissue was taken from 12 brain regions and microspheres were recovered. The relation between pump flow and embolization/g of brain was determined. Results: The mean arterial pressure at embolization was 67 ± 4 mmHg, and the range of pump flow was 0.9-3.5 l · min-1 · m-2. Cerebral blood flow was independent of pump flow. At lower pump flow, the percentage of that flow delivered to the brain increased. There was a strong inverse relation between pump flow and cerebral embolization (r = -0.708, P < 0.000 by Spearman rank order correlation). Conclusions: Cerebral embolization is determined by the CPB flow. At an unchanged mean arterial pressure, as pump flow is reduced, a progressively greater proportion of that flow is delivered to the brain.
URI: https://hdl.handle.net/11499/5582
https://doi.org/10.1097/00000542-199911000-00031
ISSN: 0003-3022
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

18
checked on Jun 22, 2024

WEB OF SCIENCETM
Citations

12
checked on Sep 24, 2024

Page view(s)

18
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.