Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5594
Title: Markers of chronic infection and inflammation. Are they important in cases with chronic coronary heart disease
Authors: Kaftan, Havane Asuman
Kaftan, O.
Kiliç, M.
Keywords: C-reactive protein
Coronary heart disease
Cytomegalovirus
Infection
c reactive protein
cytomegalovirus antibody
immunoglobulin g
adult
aged
antibody titer
article
chronic inflammation
clinical article
controlled study
coronary artery disease
female
human
human cytomegalovirus
ischemic heart disease
male
prevalence
priority journal
virus infection
Adult
Aged
Antibodies, Anti-Idiotypic
Antibodies, Viral
Biological Markers
C-Reactive Protein
Case-Control Studies
Chi-Square Distribution
Chronic Disease
Coronary Arteriosclerosis
Coronary Disease
Cytomegalovirus Infections
Female
Humans
Immunoglobulin G
Middle Aged
Multivariate Analysis
Abstract: The human cytomegalovirus plays a causal role in atherosclerosis etiology, but it is discussed as controversial. We conducted a case control study to investigate whether previous infection with cytomegalovirus is associated with coronary heart disease and markers of systemic inflammation, because systemic inflammation may play a role in atherosclerosis too. We also studied the correlation between anti-cytomegalovirus antibody titer and coronary artery disease. The study involved 150 cases (45 females, mean age ± SD is 58.73 ± 7.68 years) with a documented coronary heart disease and 160 healthy volunteers (50 females, mean age ± SD is 57.82 ± 7.68, p > 0.05). Cytomegalovirus serology was performed to determine the presence of specific IgG antibodies and titers of the anti-cytomegalovirus IgG antibodies. In addition, C-Reactive protein levels were determined for each case. The prevalance of specific antibodies to cytomegalovirus was 57.30% for the patients and 56% for the controls (p = 0.39). But higher levels of anti-cytomegalovirus IgG antibody titer (> 1/ 800) were seen in the patient group (28.6% versus 10%, p = 0.0000). Mean value of C-reactive protein was higher in the patient group (2.99 ± 0.92 mg/l versus 1.79 ± 0.51 mg/l, p = 0.0000), and there was a linar correlation with the high antibody titers and the level of C-reactive protein (r = 0.35, p = 0.0000). These findings support that not the seropositivity of the population but rather the titer of anti-cytomegalovirus antibody and the levels of C-reactive protein could predict patients with a high risk of coronary heart disease.
URI: https://hdl.handle.net/11499/5594
https://doi.org/10.1536/jhj.40.275
ISSN: 0021-4868
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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