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https://hdl.handle.net/11499/5594
Title: | Markers of chronic infection and inflammation. Are they important in cases with chronic coronary heart disease | Authors: | Kaftan, Havane Asuman Kaftan, O. Kiliç, M. |
Keywords: | C-reactive protein Coronary heart disease Cytomegalovirus Infection c reactive protein cytomegalovirus antibody immunoglobulin g adult aged antibody titer article chronic inflammation clinical article controlled study coronary artery disease female human human cytomegalovirus ischemic heart disease male prevalence priority journal virus infection Adult Aged Antibodies, Anti-Idiotypic Antibodies, Viral Biological Markers C-Reactive Protein Case-Control Studies Chi-Square Distribution Chronic Disease Coronary Arteriosclerosis Coronary Disease Cytomegalovirus Infections Female Humans Immunoglobulin G Middle Aged Multivariate Analysis |
Abstract: | The human cytomegalovirus plays a causal role in atherosclerosis etiology, but it is discussed as controversial. We conducted a case control study to investigate whether previous infection with cytomegalovirus is associated with coronary heart disease and markers of systemic inflammation, because systemic inflammation may play a role in atherosclerosis too. We also studied the correlation between anti-cytomegalovirus antibody titer and coronary artery disease. The study involved 150 cases (45 females, mean age ± SD is 58.73 ± 7.68 years) with a documented coronary heart disease and 160 healthy volunteers (50 females, mean age ± SD is 57.82 ± 7.68, p > 0.05). Cytomegalovirus serology was performed to determine the presence of specific IgG antibodies and titers of the anti-cytomegalovirus IgG antibodies. In addition, C-Reactive protein levels were determined for each case. The prevalance of specific antibodies to cytomegalovirus was 57.30% for the patients and 56% for the controls (p = 0.39). But higher levels of anti-cytomegalovirus IgG antibody titer (> 1/ 800) were seen in the patient group (28.6% versus 10%, p = 0.0000). Mean value of C-reactive protein was higher in the patient group (2.99 ± 0.92 mg/l versus 1.79 ± 0.51 mg/l, p = 0.0000), and there was a linar correlation with the high antibody titers and the level of C-reactive protein (r = 0.35, p = 0.0000). These findings support that not the seropositivity of the population but rather the titer of anti-cytomegalovirus antibody and the levels of C-reactive protein could predict patients with a high risk of coronary heart disease. | URI: | https://hdl.handle.net/11499/5594 https://doi.org/10.1536/jhj.40.275 |
ISSN: | 0021-4868 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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