Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5597
Title: Experimental study on the role of mast cells in peritoneal adhesion formation
Authors: Cantürk, N.Z.
Vural, B.
Cubukcu, A.
Duzcen, E.
Utkan, Z.
Dülger, M.
Keywords: cromoglycate disodium
anesthesia
animal cell
animal experiment
animal model
animal tissue
article
cecum
controlled study
drug response
female
intraperitoneal drug administration
laparotomy
male
mast cell
nonhuman
peritoneum adhesion
rat
Turkey (republic)
Adhesions
Animals
Anti-Inflammatory Agents
Cromolyn Sodium
Female
Male
Mast Cells
Peritoneal Diseases
Postoperative Complications
Rats
Rats, Wistar
Statistics, Nonparametric
Animalia
Abstract: Objective: To investigate the potential role of mast cell stabilisation in the prevention of post-operative adhesions. Design: Laboratory animal experiment. Setting: University hospital, Turkey. Subjects: Ninety Wistar albino rats. Intervention: Under anaesthesia, a lower midline laparotomy was performed, the caecum exposed and grasped until haemorrhage occurred. The rats were divided into three groups. Group 1, 2 and 3 were intra-peritoneally administered 1 ml of saline, disodium cromoglycate 5 mg/kg in 1 ml of saline and 10 mg/kg in 1 ml of saline, respectively thirty minutes prior to laparotomy and immediately subsequent to abdominal closure. They were later sacrificed, laparotomy repeated and the presence and extent of intraabdominal adhesions evaluated. Results: Adhesion scores were best in the high disodium cromoglycate dose group of rats (p < 0.05) and the number of degranulated mast cells was significantly low in this group (p < 0.05). Conclusion: Disodinm cromoglycate may be an effective agent for attenuating adhesion formation when administered in suitable doses.
URI: https://hdl.handle.net/11499/5597
ISSN: 0012-835X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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