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https://hdl.handle.net/11499/5597
Title: | Experimental study on the role of mast cells in peritoneal adhesion formation | Authors: | Cantürk, N.Z. Vural, B. Cubukcu, A. Duzcen, E. Utkan, Z. Dülger, M. |
Keywords: | cromoglycate disodium anesthesia animal cell animal experiment animal model animal tissue article cecum controlled study drug response female intraperitoneal drug administration laparotomy male mast cell nonhuman peritoneum adhesion rat Turkey (republic) Adhesions Animals Anti-Inflammatory Agents Cromolyn Sodium Female Male Mast Cells Peritoneal Diseases Postoperative Complications Rats Rats, Wistar Statistics, Nonparametric Animalia |
Abstract: | Objective: To investigate the potential role of mast cell stabilisation in the prevention of post-operative adhesions. Design: Laboratory animal experiment. Setting: University hospital, Turkey. Subjects: Ninety Wistar albino rats. Intervention: Under anaesthesia, a lower midline laparotomy was performed, the caecum exposed and grasped until haemorrhage occurred. The rats were divided into three groups. Group 1, 2 and 3 were intra-peritoneally administered 1 ml of saline, disodium cromoglycate 5 mg/kg in 1 ml of saline and 10 mg/kg in 1 ml of saline, respectively thirty minutes prior to laparotomy and immediately subsequent to abdominal closure. They were later sacrificed, laparotomy repeated and the presence and extent of intraabdominal adhesions evaluated. Results: Adhesion scores were best in the high disodium cromoglycate dose group of rats (p < 0.05) and the number of degranulated mast cells was significantly low in this group (p < 0.05). Conclusion: Disodinm cromoglycate may be an effective agent for attenuating adhesion formation when administered in suitable doses. | URI: | https://hdl.handle.net/11499/5597 | ISSN: | 0012-835X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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