Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5598
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dc.contributor.authorHatip-Al-Khatib, İzzettin-
dc.contributor.authorBölükbaşı, Funda-
dc.date.accessioned2019-08-16T11:50:19Z
dc.date.available2019-08-16T11:50:19Z
dc.date.issued1999-
dc.identifier.issn0091-3057-
dc.identifier.urihttps://hdl.handle.net/11499/5598-
dc.identifier.urihttps://doi.org/10.1016/S0091-3057(98)00169-5-
dc.description.abstractIn this study we investigated the effect of lesioning the noradrenergic systems on the behavioral effects of (5R, 10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5,10-imine hydrogen maleate-MK-801, in rats. The noradrenergic system was lesioned with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride-DSP4 (60 mg/kg IP). MK-801 increased the locomotor activity and rearing. DSP4 significantly further increased the hyperlocomotor activity, circling (especially to the left side), sniffing, rolling, and falling that were induced by MK-801. These results showed that destruction of the noradrenergic system increased MK-801-hyperlocomotor activity, ataxia and stereotypy. Copyright (C) 1999 Elsevier Science Inc.en_US
dc.language.isoenen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtaxiaen_US
dc.subjectDSP4en_US
dc.subjectHyperlocomotor activityen_US
dc.subjectMK-801en_US
dc.subjectNoradrenalineen_US
dc.subjectRaten_US
dc.subjectStereotypyen_US
dc.subject2 bromo n (2 chloroethyl) n ethylbenzylamineen_US
dc.subjectdizocilpineen_US
dc.subjectanimal experimenten_US
dc.subjectarticleen_US
dc.subjectataxiaen_US
dc.subjectbehavioren_US
dc.subjectcircling behavioren_US
dc.subjectcontrolled studyen_US
dc.subjectintraperitoneal drug administrationen_US
dc.subjectlocomotionen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectnoradrenergic systemen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectrearingen_US
dc.subjectstereotypyen_US
dc.subjectAdrenergic Agentsen_US
dc.subjectAnimalsen_US
dc.subjectBehavior, Animalen_US
dc.subjectBenzylaminesen_US
dc.subjectDizocilpine Maleateen_US
dc.subjectDrug Synergismen_US
dc.subjectExcitatory Amino Acid Antagonistsen_US
dc.subjectMaleen_US
dc.subjectMotor Activityen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectStereotyped Behavioren_US
dc.titleDestruction of the noradrenergic system with DSP4 potentiates the behavioral effects of MK-801 in ratsen_US
dc.typeArticleen_US
dc.identifier.volume62en_US
dc.identifier.issue2en_US
dc.identifier.startpage233
dc.identifier.startpage233en_US
dc.identifier.endpage237en_US
dc.authorid0000-0002-9127-6779-
dc.identifier.doi10.1016/S0091-3057(98)00169-5-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid9972689en_US
dc.identifier.scopus2-s2.0-0032941759en_US
dc.identifier.wosWOS:000078215700007en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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