Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56054
Title: Molecular epidemiological investigation of carbapenem resistant Klebsiella pneumoniae isolated from intensive care unit patients of six geographical regions of Turkey
Authors: Köse, Ş.
Dal, T.
Çetinkaya, R.A.
Arı, O.
Yenilmez, E.
Temel, E.N.
Çetin, E.S.
Arabacı, Çiğdem
Büyüktuna, Seyit Ali
Hasbek, Mürşit
Külahlıoğlu, Neslihan
Müderris, Tuba
Kaynar, Teoman
Sarı, Tuğba
Yalçın, Ata Nevzat
Ak, Kenan
Yıldırım, Berivan Tunca
Şahin, Merve
Durmaz, Rıza
Keywords: carbapenem
colistin
K. pneumonia
MLST
antiinfective agent
beta lactamase
carbapenem derivative
colistin
carbapenem-resistant Enterobacteriaceae
genetics
human
intensive care unit
Klebsiella infection
Klebsiella pneumoniae
microbial sensitivity test
multidrug resistance
multilocus sequence typing
turkey (bird)
Anti-Bacterial Agents
beta-Lactamases
Carbapenem-Resistant Enterobacteriaceae
Carbapenems
Colistin
Drug Resistance, Multiple, Bacterial
Humans
Intensive Care Units
Klebsiella Infections
Klebsiella pneumoniae
Microbial Sensitivity Tests
Multilocus Sequence Typing
Turkey
Publisher: Journal of Infection in Developing Countries
Abstract: Introduction: Klebsiella pneumonia causes serious infections in hospitalized patients. In recent years, carbapenem-resistant infections increased in the world. The molecular epidemiological investigation of carbapenem-resistant K. pneumoniae isolates was aimed in this study. Methodology: Fifty carbapenem-resistant K. pneumoniae isolates from six geographical regions of Turkey between September 2019-2020 were included in the study. The disk diffusion method was used for the antibiotic susceptibility testing. The microdilution confirmed colistin susceptibility. Genetic diversity was investigated by MLST (Multi-Locus Sequence Typing). Results: The resistance rates were as follows: 49 (98%) for meropenem, 47 (94%) imipenem, 50 (100%) ertapenem, 30 (60%) colistin and amoxicillin-clavulanate, 49 (98%) ceftriaxone, 48 (96%) cefepime, 50 (100%) piperacillin-tazobactam, 47 (94%) ciprofloxacin, 40 (80%) amikacin, 37 (74%) gentamicin. An isolate resistant to colistin by disk diffusion was found as susceptible to microdilution. ST 2096 was the most common (n:16) sequence type by MLST. ST 101 (n:7), ST14 (n:6), ST 147 and ST 15 (n:4), ST391 (n:3), ST 377 and ST16 (n:2), ST22, ST 307, ST 985, ST 336, ST 345, and ST 3681 (n:1) were classified in other isolates. In İstanbul and Ankara ST2096 was common. Among Turkey isolates, the most common clonal complexes (CC) were CC14 (n:26) and CC11 (n = 7). Conclusions: In Turkey, a polyclonal population of CC14 throughout the country and inter-hospital spread were indicated. The use of molecular typing tools will highlight understanding the transmission dynamics. Copyright © 2023 Köse et al.
URI: http://dx.doi.org/10.3855/jidc.17651
https://hdl.handle.net/11499/56054
ISSN: 2036-6590
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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