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Title: | Molecular epidemiological investigation of carbapenem resistant Klebsiella pneumoniae isolated from intensive care unit patients of six geographical regions of Turkey | Authors: | Köse, Ş. Dal, T. Çetinkaya, R.A. Arı, O. Yenilmez, E. Temel, E.N. Çetin, E.S. Arabacı, Çiğdem Büyüktuna, Seyit Ali Hasbek, Mürşit Külahlıoğlu, Neslihan Müderris, Tuba Kaynar, Teoman Sarı, Tuğba Yalçın, Ata Nevzat Ak, Kenan Yıldırım, Berivan Tunca Şahin, Merve Durmaz, Rıza |
Keywords: | carbapenem colistin K. pneumonia MLST antiinfective agent beta lactamase carbapenem derivative colistin carbapenem-resistant Enterobacteriaceae genetics human intensive care unit Klebsiella infection Klebsiella pneumoniae microbial sensitivity test multidrug resistance multilocus sequence typing turkey (bird) Anti-Bacterial Agents beta-Lactamases Carbapenem-Resistant Enterobacteriaceae Carbapenems Colistin Drug Resistance, Multiple, Bacterial Humans Intensive Care Units Klebsiella Infections Klebsiella pneumoniae Microbial Sensitivity Tests Multilocus Sequence Typing Turkey |
Publisher: | Journal of Infection in Developing Countries | Abstract: | Introduction: Klebsiella pneumonia causes serious infections in hospitalized patients. In recent years, carbapenem-resistant infections increased in the world. The molecular epidemiological investigation of carbapenem-resistant K. pneumoniae isolates was aimed in this study. Methodology: Fifty carbapenem-resistant K. pneumoniae isolates from six geographical regions of Turkey between September 2019-2020 were included in the study. The disk diffusion method was used for the antibiotic susceptibility testing. The microdilution confirmed colistin susceptibility. Genetic diversity was investigated by MLST (Multi-Locus Sequence Typing). Results: The resistance rates were as follows: 49 (98%) for meropenem, 47 (94%) imipenem, 50 (100%) ertapenem, 30 (60%) colistin and amoxicillin-clavulanate, 49 (98%) ceftriaxone, 48 (96%) cefepime, 50 (100%) piperacillin-tazobactam, 47 (94%) ciprofloxacin, 40 (80%) amikacin, 37 (74%) gentamicin. An isolate resistant to colistin by disk diffusion was found as susceptible to microdilution. ST 2096 was the most common (n:16) sequence type by MLST. ST 101 (n:7), ST14 (n:6), ST 147 and ST 15 (n:4), ST391 (n:3), ST 377 and ST16 (n:2), ST22, ST 307, ST 985, ST 336, ST 345, and ST 3681 (n:1) were classified in other isolates. In İstanbul and Ankara ST2096 was common. Among Turkey isolates, the most common clonal complexes (CC) were CC14 (n:26) and CC11 (n = 7). Conclusions: In Turkey, a polyclonal population of CC14 throughout the country and inter-hospital spread were indicated. The use of molecular typing tools will highlight understanding the transmission dynamics. Copyright © 2023 Köse et al. | URI: | http://dx.doi.org/10.3855/jidc.17651 https://hdl.handle.net/11499/56054 |
ISSN: | 2036-6590 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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