Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5608
Title: Somatostatin: Possible cause of bacterial translocation in obstructive jaundiced rats
Authors: Sungurtekin, Hülya
Ozden, A.
Kaleli, I.
Sungurtekin, U.
Gonullu, M.
Keywords: Bacteria
Jaundice
Somatostatin
Translocation
alkaline phosphatase
bilirubin
hormone
somatostatin
analysis of variance
animal
article
bacterial translocation
blood
chi square distribution
cholestasis
drug effect
male
microbiology
rat
sepsis
Sprague Dawley rat
Alkaline Phosphatase
Analysis of Variance
Animals
Bacterial Translocation
Bilirubin
Chi-Square Distribution
Cholestasis
Hormones
Male
Rats
Rats, Sprague-Dawley
Sepsis
Publisher: Springer Japan
Abstract: The purpose of this study was to examine the effect of endogenous somatostatin hormone on bacterial translocation in obstructive jaundiced rats. Five groups of rats were studied: group I (n = 10), non-operated group (control); group II (n = 10), sham-operated group which underwent laparotomy and dissection of portal elements, while the common bile duct was not ligated and somatostatin was not injected; group III (n = 10), same as group II, plus injection of somatostatin; group IV (n = 10), common bile duct was ligated with laparotomy but somatostatin was not injected; group V (n = 10), same as group IV, plus somatostatin injection. The blood was analyzed for somatostatin, alkaline phosphatase, and bilirubin levels on the third and tenth days in all animals. At study termination (tenth day), peritoneal swab and blood cultures were taken, and liver, spleen, lung, and mesenteric lymph nodes were harvested for microbiological studies. Bacterial translocation levels were higher in groups III, IV, and V when compared with levels in groups I and II. Similar translocation levels were obtained when blood somatostatin levels were comparable. However, the highest translocation rate was found in groups IV and V in which the blood somatostatin level was also higher when compared with that in other groups. This finding shows that blood somatostatin level is increased in obstructive jaundice. This may explain the bacterial translocation and related sepsis found in obstructive jaundice. © Springer-Verlag 1999.
URI: https://hdl.handle.net/11499/5608
https://doi.org/10.1007/s005340050140
ISSN: 0944-1166
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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