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https://hdl.handle.net/11499/56082
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DC Field | Value | Language |
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dc.contributor.author | Ulutaş, Firdevs | - |
dc.contributor.author | Çetin, Gökhan Ozan | - |
dc.contributor.author | Çobankara, Veli | - |
dc.date.accessioned | 2023-12-16T06:45:21Z | - |
dc.date.available | 2023-12-16T06:45:21Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2149-3189 | - |
dc.identifier.uri | http://dx.doi.org/10.18621/eurj.1082965 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/1207238 | - |
dc.identifier.uri | https://hdl.handle.net/11499/56082 | - |
dc.description.abstract | Objectives: Osteoporosis (OP) is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts. Recent animal and human trials have revealed the main pro-osteoclastogenic activities for the IL-23 pathway. We examined nine single nucleotide polymorphisms (SNPs) in the interleukin-23 receptor (IL-23R) in 100 OP patients and gender- and age-matched 96 healthy volunteers. The most analyzed SNPs in the recent rheumatology literature were selected. Methods: In addition to gene polymorphisms several laboratory parameters (osteocalcin, parathormone, vitamine D) were investigated. Independent Samples t-test and Mann-Whitney-U test were used to compare several demographic and clinical parameters between the groups. P-value < 0.05 was accepted to be statistically significant. Results: Having the heterozygous GA genotype of IL-23R rs1004819 and the heterozygous CT genotype of Il-23R rs7530511 significantly increase the risk of developing OP (adjusted OR: 3.51, p = 0.031 and OR: 2.41, p = 0.027, respectively). The wild homozygous GG genotype of Il-23R rs11209032 had higher osteocalcin levels compared with the mutant homozygous AA genotype (18.75 ± 9.76, p = 0.009). Conclusions: Our findings suggest that several IL-23R gene polymorphisms are seen more often in osteoporosis patients than in healthy volunteers. In addition, some SNPs were related to higher serum osteocalcin levels. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | The European Research Journal | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Interleukin-23 receptor gene polymorphisms in osteoporosis | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 1277 | en_US |
dc.identifier.endpage | 1285 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.18621/eurj.1082965 | - |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.trdizinid | 1207238 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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document - 2024-04-02T162543.090.pdf | 896.53 kB | Adobe PDF | View/Open |
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