Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5613
Title: Effect of nitric oxide on postoperative adhesion formation
Authors: Özden, Akın
Bostancı, Birol
Sarioglu, Akile
Ta¸kiran, D.
Tetik, Cihat
Keywords: Adhesion formation
L-arginine
Nitric oxide
Nitrite/nitrate (NOx)
N?-nitro arginine methyl ester
Peritoneal adhesion
n(g) nitroarginine methyl ester
nitric oxide
abdominal surgery
animal experiment
animal model
article
controlled study
male
nonhuman
peritoneum adhesion
priority journal
rat
Publisher: S. Karger AG
Abstract: Peritoneal adhesions continue to be a significant cause of postoperative complications. The purpose of the present study was to investigate the effect of nitric oxide in preventing postoperative adhesion formation in rats. Three randomized groups of Sprague-Dawley rats were subjected to a standardized lesion by cecal abrasion and parietal peritoneal defect. 0.9% NaCl (control, group 1), L-arginine (300 mg/kg, group 2) and N?-nitro arginine methyl ester (L-NAME; 25 mg/kg, group 3) were administered intraperitoneally before abdominal closure and during 3 consecutive days after surgery. Two weeks after surgery, a relaparotomy was performed and the extent of adhesion formation was determined. In groups 1 and 3 heavy adhesions were detected. In the L-arginine group, adhesion formation was significantly less than in the other groups (p < 0.05). This study showed that L-arginine reduced adhesion formation.
URI: https://hdl.handle.net/11499/5613
https://doi.org/10.1159/000008726
ISSN: 0014-312X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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