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https://hdl.handle.net/11499/5613
Title: | Effect of nitric oxide on postoperative adhesion formation | Authors: | Özden, Akın Bostancı, Birol Sarioglu, Akile Ta¸kiran, D. Tetik, Cihat |
Keywords: | Adhesion formation L-arginine Nitric oxide Nitrite/nitrate (NOx) N?-nitro arginine methyl ester Peritoneal adhesion n(g) nitroarginine methyl ester nitric oxide abdominal surgery animal experiment animal model article controlled study male nonhuman peritoneum adhesion priority journal rat |
Publisher: | S. Karger AG | Abstract: | Peritoneal adhesions continue to be a significant cause of postoperative complications. The purpose of the present study was to investigate the effect of nitric oxide in preventing postoperative adhesion formation in rats. Three randomized groups of Sprague-Dawley rats were subjected to a standardized lesion by cecal abrasion and parietal peritoneal defect. 0.9% NaCl (control, group 1), L-arginine (300 mg/kg, group 2) and N?-nitro arginine methyl ester (L-NAME; 25 mg/kg, group 3) were administered intraperitoneally before abdominal closure and during 3 consecutive days after surgery. Two weeks after surgery, a relaparotomy was performed and the extent of adhesion formation was determined. In groups 1 and 3 heavy adhesions were detected. In the L-arginine group, adhesion formation was significantly less than in the other groups (p < 0.05). This study showed that L-arginine reduced adhesion formation. | URI: | https://hdl.handle.net/11499/5613 https://doi.org/10.1159/000008726 |
ISSN: | 0014-312X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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