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https://hdl.handle.net/11499/56280
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tüfekçi, Ali Rıza | - |
dc.contributor.author | Demirtaş, İbrahim | - |
dc.contributor.author | Akşit, Hüseyin | - |
dc.contributor.author | Arslan, Şevki | - |
dc.contributor.author | Kocabıyık, Kübra | - |
dc.contributor.author | Zeybek, Sibel | - |
dc.contributor.author | Özen, Tevfik | - |
dc.date.accessioned | 2024-01-21T19:50:27Z | - |
dc.date.available | 2024-01-21T19:50:27Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1747-0277 | - |
dc.identifier.issn | 1747-0285 | - |
dc.identifier.uri | https://doi.org/10.1111/cbdd.14409 | - |
dc.identifier.uri | https://hdl.handle.net/11499/56280 | - |
dc.description.abstract | Centaurea paphlagonica (Bornm.) Wagenitz is an endemic plant in Turkey. Pyrocatechol, vanillic acid, 3,4-dihydroxy benzoic acid, 5-O-caffeoylshikimic acid, tamarixetin, chlorogenic acid methyl ester, quercetin, 1,3-dicaffeoylquinic acid, tamarixetin-7-O-beta-D-glucopyranoside, quercimetrin, daucosterin, paphlagonicanin B, tamarixetin-7-O-beta-rutinoside, rutin, chlorogenic acid, isoorientin, orientin, 3-O- feruloylquinic acid, quercetagetin-3-methyl ether 6-O-beta-glucopyranoside, diosmetin 6-C-beta-glucopyranoside, quercetagetin 4 '-methyl ether 7-O-beta-glucopyranoside, paphlagonicanin A, nepetin, cirsiliol, desacylcynaropicrin, and 8 alpha-O-(2 ',3 '- dihydroxyisobutyryl) desacylcynaropicrin were isolated from both flower and aerial parts of C. paphlagonica. These compounds were identified using 1D and 2D NMR methods and ESI-MS. The MTT assay assessed the antiproliferative activities of all isolated (known and new compounds) compounds on Caco-2, LNCaP, A549, HeLa, and HEK-293 cell lines. The 8 alpha-O-(2 ',3 '-dihydroxyisobutyryl) desacylcynaropicrin demonstrated the highest activity against CaCo-2 and HeLa cancer cell lines. | en_US |
dc.description.sponsorship | Cankimath;rimath; Karatekin University Scientific Research Projects Unit [2013/16] | en_US |
dc.description.sponsorship | Cank & imath;r & imath; Karatekin University Scientific Research Projects Unit, Grant/Award Number: 2013/16 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Chemical Biology & Drug Design | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | antiproliferative activity | en_US |
dc.subject | Asteraceae | en_US |
dc.subject | Centaurea paphlagonica | en_US |
dc.subject | isolation | en_US |
dc.subject | MTT | en_US |
dc.subject | Bioactivity-Guided Isolation | en_US |
dc.subject | Antimicrobial Activity | en_US |
dc.subject | Antiproliferative Compounds | en_US |
dc.subject | Essential Oil | en_US |
dc.subject | Aerial Parts | en_US |
dc.subject | Sesquiterpene Lactones | en_US |
dc.subject | Chemical-Composition | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Extract | en_US |
dc.title | Two new compounds from endemic Centaurea paphlagonica (Bornm.) Wagenitz and their cytotoxic activities | en_US |
dc.type | Article | en_US |
dc.type | Article; Early Access | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | TUFEKCI, ALI RIZA/0000-0002-2951-3657 | - |
dc.identifier.doi | 10.1111/cbdd.14409 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 55266057300 | - |
dc.authorscopusid | 6701658113 | - |
dc.authorscopusid | 35079983400 | - |
dc.authorscopusid | 8684142100 | - |
dc.authorscopusid | 57670939100 | - |
dc.authorscopusid | 58731996100 | - |
dc.authorscopusid | 55939045800 | - |
dc.authorwosid | aksit, huseyin/AEH-9164-2022 | - |
dc.identifier.pmid | 38030403 | en_US |
dc.identifier.scopus | 2-s2.0-85178191157 | en_US |
dc.identifier.wos | WOS:001110803200001 | en_US |
dc.institutionauthor | … | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.openairetype | Article; Early Access | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 17.02. Biology | - |
crisitem.author.dept | 17.02. Biology | - |
Appears in Collections: | Fen Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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