Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/56284
Title: | Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study | Authors: | Lektemur Alpan, Aysan Torumtay, Gizem Kızıldağ, Alper Zavrak, Necati Özmen, Özlem Arslan, Sevki Mutlu, Doğukan |
Keywords: | Blood platelets fibrin fibroblasts platelet-rich fibrin rat regeneration wound healing |
Publisher: | Taylor & Francis Ltd | Abstract: | This experimental study aimed to evaluate the effects of injectable platelet-rich fibrin (i-PRF) on mucosal healing and the release of growth factors in rats. 40 rats were used; i-PRF was administered in the right buccal area while saline was injected in the left. Cytokeratin, FGF, PDGF, TGF, and VEGF expressions were determined with immunohistochemistry. Gene expressions of EGF, TGF-beta, and VEGF were analysed. Epithelialization started on the 3rd day, and connective tissue maturation was more prominent in the i-PRF-applied group. Also, the releases of VEGF, EGF, TGF-beta, PDGF, and FGF were higher in the i-PRF group during the 14 days. Gene expression analysis showed that changes in TGF-beta at 14 days after i-PRF injection and VEGF after 21 days were statistically significant. The results of this study suggested that autologous i-PRF application enhanced the healing of oral mucosal wounds by increasing the release of growth factors for 21 days. | URI: | https://doi.org/10.1080/08977194.2023.2289375 https://hdl.handle.net/11499/56284 |
ISSN: | 0897-7194 1029-2292 |
Appears in Collections: | Fen Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
4
checked on Dec 21, 2024
WEB OF SCIENCETM
Citations
3
checked on Dec 19, 2024
Page view(s)
64
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.