Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56284
Title: Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study
Authors: Lektemur Alpan, Aysan
Torumtay, Gizem
Kızıldağ, Alper
Zavrak, Necati
Özmen, Özlem
Arslan, Sevki
Mutlu, Doğukan
Keywords: Blood platelets
fibrin
fibroblasts
platelet-rich fibrin
rat
regeneration
wound healing
Publisher: Taylor & Francis Ltd
Abstract: This experimental study aimed to evaluate the effects of injectable platelet-rich fibrin (i-PRF) on mucosal healing and the release of growth factors in rats. 40 rats were used; i-PRF was administered in the right buccal area while saline was injected in the left. Cytokeratin, FGF, PDGF, TGF, and VEGF expressions were determined with immunohistochemistry. Gene expressions of EGF, TGF-beta, and VEGF were analysed. Epithelialization started on the 3rd day, and connective tissue maturation was more prominent in the i-PRF-applied group. Also, the releases of VEGF, EGF, TGF-beta, PDGF, and FGF were higher in the i-PRF group during the 14 days. Gene expression analysis showed that changes in TGF-beta at 14 days after i-PRF injection and VEGF after 21 days were statistically significant. The results of this study suggested that autologous i-PRF application enhanced the healing of oral mucosal wounds by increasing the release of growth factors for 21 days.
URI: https://doi.org/10.1080/08977194.2023.2289375
https://hdl.handle.net/11499/56284
ISSN: 0897-7194
1029-2292
Appears in Collections:Fen Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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