Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56294
Title: Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study
Authors: Doğan, Çagla Serpil
Taner, Sevgin
Durucu Tiryaki, Betül
Alaygut, Demet
Özkayın, Neşe
Kara, Aslıhan
Gencler, Aylin
Pınarbaşı, Ayşe Seda
Nalçacıoğlu, Hülya
Yüksel, Selçuk
Akacı, Okan
Yılmaz, Esra Karabağ
Yavuz, Sevgi
Doğan, Kenan
Gülşan, Rumeysa Yasemin Çiçek
Aksoy, Gülşah Kaya
Çiçek, Neslihan
Aksu, Bağdagül
Küçük, Nuran
Altugan, Fatma Şemsa
Selçuk, Şenay Zırhlı
Baştuğ, Funda
Erfidan, Gökçen
Atmış, Bahriye
Gökçeoğlu, Arife Uslu
Önder, Esra Nagehan Akyol
Elmacı, Ahmet Mithat
Cengiz, Nurcan
Gülleroğlu, Kaan
Yılmaz, Ebru Bekiroğlu
Tayfur, Aslı Çelebi
Yılmaz, Gülsün Gülay
Yel, Sİbel
Pehlivanoğlu, Cemile
Kara, Mehtap Akbalık
Kılıç, Beltinge Demircioğlu
Şimşek, Özgür Özdemir
Yucal, Melike
Ağar, Buket Esen
Gürgöze, Metin Kaya
Yağmur, İsmail
Madsar, Ömer
Karalı, Demet Tekcan
Girişgen, İlknur
Bodur, Ece Demirci
Çomak, Elif
Gökçe, İbrahim
Kaya, Mehtap
Tabel, Yılmaz
Günay, Neslihan
Gülmez, Rüveyda
Çalışkan, Salim
Keywords: Child
Myelomeningocele
Neurogenic bladder
Predictors
Chronic kidney disease
Spina-Bifida
Neurogenic Bladder
Renal-Function
Management
Adolescents
Publisher: Springer
Abstract: Background Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.Methods Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.Results A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.Conclusion MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.
URI: https://doi.org/10.1007/s00467-023-06212-5
https://hdl.handle.net/11499/56294
ISSN: 0931-041X
1432-198X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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