Auditory evoked potentials in vitiligo patients

Abstract

There is convincing evidence that vitiligo is a systemic disorder influencing the whole pigmentary system, including melanocytes in the inner ear. Cochlear melanocytes and also melanin-containing cellular elements of the auditory system may be affected in vitiligo and interfere with the conduction of action potentials. We conducted a prospective clinical trial to determine hearing status and auditory evoked potentials in 50 patients affected by vitiligo and compared the results with those of 50 healthy controls. I, III, V latencies and amplitudes and I-III, III-V, I-V interpeak latencies were compared with each group. Statistical evaluation was accomplished using the t-test. With the exception of two subjects, all patients demonstrated normal audiological results. No statistically significant difference was noted between the study group and controls in regard to latencies, interpeak latencies and amplitudes. We conclude that auditory investigations supported by postmortem histopathological studies of the inner ear and brainstem may provide more accurate knowledge in vitiligo patients.