The Prognostic Factors in Endometrial Cancers Treated with Radiotherapy: Retrospective Analysis

Abstract

Introduction: Endometrial cancer is mostly diagnosed in the early stages and has a good prognosis. Surgery has main role in the treatment of patients with endometrial cancer and adjuvant radiotherapy (RT) is administered in certain risk groups. In this retrospective study, we analyzed the factors affecting the prognosis of patients with endometrial cancer who underwent RT. Materials and methods: A total of 181 patients who were diagnosed with endometrial cancer were included in the study. Based on the prognostic factors, risk groups were recorded as low, intermediate, high-intermediate, high risk, and advanced/metastatic. Patients’ overall survival (OS) was calculated using Kaplan– Meier method. Results: Median age was 60 years (range, 28–82). The number of patients who received adjuvant RT alone, RT and chemotherapy, and chemotherapy alone were 77 (42.5%), 65 (36%), and 39 (21.5%), respectively. Median OS was 12.4 years (range, 0.1-21). Except for the advanced/metastatic risk group, OS was better in all the other risk groups who received RT alone (p<0.001). Discussion: Risk groups (based on prognostic risk factors), p53, and treatment applied (RT alone) are the significant prognostic indicators for patients received adjuvant therapy in endometrial cancer. Adding adjuvant chemotherapy to RT adversely affects the prognosis.