Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/5640
Title: | Pentoxifylline reduces injury of the brain in transient ischaemia | Authors: | Hayrettin Şirin, B. Yılık, Levent Coşkun, Erdal Ortaç, R. Şirin, Hadiye |
Keywords: | Cerebral ischaemio Cerebral protection Pentoxifylline Rat Somatosensory evoked potentials pentoxifylline peripheral vasodilating agent animal experiment animal tissue article brain injury brain ischemia brain perfusion carotid artery obstruction controlled study evoked somatosensory response histopathology male nonhuman prospective study rat reperfusion transient ischemic attack Animals Brain Evoked Potentials, Somatosensory Ischemic Attack, Transient Male Neurologic Examination Pyramidal Cells Rats Rats, Wistar Regional Blood Flow Reperfusion Injury Vasodilator Agents |
Abstract: | Objective - The beneficial effect of pentoxifylline (PTX) on ischaemic-reperfusion injury was assessed in a rat model of transient global cerebral ischaemia. Design - Randomized, controlled, prospective study. Setting - University research laboratory. Subjects - Thirty-six male Wistar albino rats. Interventions - Ischaemia was induced with a four-vessel occlusion technique in 24 animals with the duration of 15 minutes. Group I animals (n = 12) received PTX treatment started 20 minutes before the occlusion of carotid arteries (60 mg/kg bolus followed by infusion at 0.1 mg/kg/min). A similar volume of saline solution was used in animals of the control group (group 2, n = 12). The animals in group 3 (sham group, n = 12) were anaesthetized and subjected to operative dissections without vascular occlusion. Measurements - Physiological parameters and somatosensory evoked potentials (SEP) were monitored in animals before ischaemia, during ischaemia and in the first 30 minutes of reperfusion. Their neurological outcome had been clinically evaluated and scored up to 4 days post ischaemia. The intergroup differences were compared. Then the animals were sacrificed and their brains were processed for histopathological examination. Main results - In group 3, SEP amplitudes did not change during the procedures, and all animals recovered without neurologic deficits. At the end of the ischaemic period, the average amplitude was reduced to 4 ± 3% of the baseline in all ischaemic animals. This was followed by a gradual return to 92 ± 9% and 82 ± 8% of the initial amplitude after 30 minutes of reperfusion in group 1 and group 2, respectively (p < 0.05). The average neurological score was significantly higher in group 1 than in group 2 in the post-ischaemia period (p < 0.05). Histological observations were clearly correlated with the neurological findings. Conclusion - The results suggest that PTX reduces cerebral injury and preserves neurologic function in transient global ischaemia in rats. | URI: | https://hdl.handle.net/11499/5640 | ISSN: | 0001-5385 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
14
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
12
checked on Oct 14, 2024
Page view(s)
40
checked on Aug 24, 2024
Google ScholarTM
Check
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.