Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/5645
Title: | Cytoprotective effect of trimetazidine on 75 min warm renal ischemia-reperfusion injury in rats | Authors: | Özden, Akın Aybek, Zafer Saydam, Nurten Çallı, Neşe Saydam, Oktay Düzcan, Ender Güner, Gül |
Keywords: | Glutathione Glutathione peroxidase Ischemia-reperfusion injury Malondialdehyde Renal ischemia Trimetazidine creatinine glutathione glutathione peroxidase malonaldehyde trimetazidine acute kidney tubule necrosis animal cell animal experiment animal model animal tissue article blood sampling cell protection controlled study histopathology kidney ischemia nephrectomy nonhuman priority journal rat reperfusion injury statistical analysis survival rate Animals Ischemia Kidney Lipid Peroxidation Male Rats Rats, Sprague-Dawley Reperfusion Injury Vasodilator Agents |
Abstract: | In this experimental study, we evaluated the effect of trimetazidine (TMZ) on renal ischemia-reperfusion (IR) injury in Sprague-Dawley rats. Renal IR was achieved by a 75-min clamping of the left renal pedicle and subsequent 24 h reperfusion, after right nephrectomy was performed. The rats were randomly divided into three groups: group 1 (sham operated: no IR injury), group 2 (ischemic control: saline treatment), and group 3 (3 mg/kg TMZ before ischemia). After 24 h of reperfusion, blood samples and renal tissue samples were taken to measure the levels of creatinine, tissue malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) activity. Histopathological changes were evaluated, In addition, the 7-day survival rates in each group were evaluated. We found significant increases in the levels of creatinine and tissue MDA, severe acute tubular necrosis, and a significant decrease in the activity of the GSH-Px in group 2. There were significant decreases in the levels of creatinine and tissue MDA, mild acute tubular necrosis, and a significant increase in activity of the GSH-Px in group 3 when compared with the control group (p < 0.05). Statistically significant differences (p < 0.05) in survival were noted between the ischemic control and sham-operated and TMZ groups. We have concluded that TMZ is able to protect the kidney from warm IR injury. | URI: | https://hdl.handle.net/11499/5645 https://doi.org/10.1159/000008581 |
ISSN: | 0014-312X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
37
checked on Sep 30, 2024
WEB OF SCIENCETM
Citations
36
checked on Oct 8, 2024
Page view(s)
56
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.