Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5645
Title: Cytoprotective effect of trimetazidine on 75 min warm renal ischemia-reperfusion injury in rats
Authors: Özden, Akın
Aybek, Zafer
Saydam, Nurten
Çallı, Neşe
Saydam, Oktay
Düzcan, Ender
Güner, Gül
Keywords: Glutathione
Glutathione peroxidase
Ischemia-reperfusion injury
Malondialdehyde
Renal ischemia
Trimetazidine
creatinine
glutathione
glutathione peroxidase
malonaldehyde
trimetazidine
acute kidney tubule necrosis
animal cell
animal experiment
animal model
animal tissue
article
blood sampling
cell protection
controlled study
histopathology
kidney ischemia
nephrectomy
nonhuman
priority journal
rat
reperfusion injury
statistical analysis
survival rate
Animals
Ischemia
Kidney
Lipid Peroxidation
Male
Rats
Rats, Sprague-Dawley
Reperfusion Injury
Vasodilator Agents
Abstract: In this experimental study, we evaluated the effect of trimetazidine (TMZ) on renal ischemia-reperfusion (IR) injury in Sprague-Dawley rats. Renal IR was achieved by a 75-min clamping of the left renal pedicle and subsequent 24 h reperfusion, after right nephrectomy was performed. The rats were randomly divided into three groups: group 1 (sham operated: no IR injury), group 2 (ischemic control: saline treatment), and group 3 (3 mg/kg TMZ before ischemia). After 24 h of reperfusion, blood samples and renal tissue samples were taken to measure the levels of creatinine, tissue malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) activity. Histopathological changes were evaluated, In addition, the 7-day survival rates in each group were evaluated. We found significant increases in the levels of creatinine and tissue MDA, severe acute tubular necrosis, and a significant decrease in the activity of the GSH-Px in group 2. There were significant decreases in the levels of creatinine and tissue MDA, mild acute tubular necrosis, and a significant increase in activity of the GSH-Px in group 3 when compared with the control group (p < 0.05). Statistically significant differences (p < 0.05) in survival were noted between the ischemic control and sham-operated and TMZ groups. We have concluded that TMZ is able to protect the kidney from warm IR injury.
URI: https://hdl.handle.net/11499/5645
https://doi.org/10.1159/000008581
ISSN: 0014-312X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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