Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56519
Title: Acute Stroke Management in Türkiye: Intravenous Tissue Plasminogen Activator and Thrombectomy NöroTek: Türkiye Neurology Single Day Study
Other Titles: Türkiye’de Akut İnme Yönetimi: IV tPA ve Trombektomi NöroTek: Türkiye Nöroloji Tek Gün Çalışması
Authors: Topçuoğlu, M.A.
Özdemir, A.Ö.
Arsava, E.M.
Güneş, A.
Aykaç, Ö.
Gencer, E.S.
Çabalar, M.
Yayla, Vildan
Erdoğan, Hacı Ali
Erdoğan, Mücahid
Acar, Zeynep Özdemir
Şener, Ufuk
Yıldız, Özlem Kayım
Bolayır, Aslı
Kısabay, Aysın
Baştan, Birgül
Acar, Zeynep
Niflioğlu, Buket
Güven, Bülent
Kaya, Dilaver
Baş, Demet Funda
İnce, Fatma Birsen
Afşar, Nazire
Yazıcı, Duran
Toplutaş, Eren
Özkan, Esra
İlik, Faik
Büyükşerbetçi, Gülseren
Aslan, Yıldız
Önder, Halil
Karadeli, Hasan Hüseyin
Kozak, Hasan Hüseyin
Demirbaş, Hayri
Midi, İpek
Aydın, İsa
Can, Ufuk
Demir, Turgay
Epçeliden, M. Tuncay
Atmaca, Murat Mert
Bakar, Mustafa
Şen, Mustafa
Turgut, Nilda
Keskin, Onur
Akdoğan, Özlem
Emre, Ufuk
Bilgili, Özlem
Demir, Tülin
Şirinocak, Pınar Bekdik
Yevgi, Recep
Akkaş, Sinem Yazıcı
Çınar, Bilge Piri
Dora, Babür
Yoldaş, Tahir
Duman, Taşkın
Atasoy, Tuğrul
Özel, Tuğba
Öztürk, Şerefnur
Ünal, Ali
Giray, Semih
Kablan, Yüksel
Tanrıverdi, Zeynep
Tekan, Ülgen Yalaz
Asil, Talip
Akpınar, Çetin Kürşad
Yürekli, Vedat Ali
Acar, Bilgehan
Akçakoyunlu, Merve
Şirin, Hadiye
Güler, Ayşe
Baydemir, Recep
Krespi, Yakup
Öcek, Levent
Çetiner, Mustafa
Nazlıel, Bijen
Çağlayan, Hale Batur
Ongun, Nedim
Eren, Alper
Arlıer, Zülfikar
Cenikli, Utku
Gökçe, Mustafa
Özkul, Ayça
Bavli, Songül
Yaka, Erdem
Özdemir, Gökhan
Değirmenci, Bahar
Aluçlu, Ufuk
Işıkay, Canan Togay
Aslanbaba, Eda
Sorgun, Mine
Aytaç, Emrah
Ay, Halil
Kunt, Refik
Şenadım, Songül
Eşkut, Neslihan
Ünsal, Yaprak Özüm
Bozdoğan, Zehra
Alioğlu, Zekeriya
Yılmaz, Arda
Genç, Hamit
Yılmaz, Ayşe
Milanoğlu, Aysel
Gürkaş, Erdem
Değirmenci, Eylem
Bektaş, Hesna
İlgezdi, İrem
Bilgiç, Adnan Burak
Yılmaz, Zahide
Akyol, Şenol
Güngör, Levent
Kale, Nilüfer
Çoban, Eda
Yeşilot, Nilüfer
Ekizoğlu, Esme
Kizek, Özgü
Kurşun, Oğuzhan
Keywords: Acute stroke
metric
prognosis
thrombectomy
thrombolytic therapy
treatment window
tissue plasminogen activator
adult
aged
Article
bleeding
blood clot lysis
brain infarction
cerebrovascular accident
computer assisted tomography
demographics
female
hospitalization
human
intensive care unit
length of stay
major clinical study
male
mechanical thrombectomy
mortality
National Institutes of Health Stroke Scale
neurothrombectomy
nuclear magnetic resonance imaging
prognosis
Rankin scale
recanalization
revascularization
thrombectomy
Publisher: Turkish Neurosurgical Society
Abstract: Objective: To reveal the profile and practice in patients with acute stroke who received intravenous tissue plasminogen activator (IV tPA) and/or neuro-interventional therapy in Türkiye. Materials and Methods: On World Stroke Awareness Day, May 10, 2018, 1,790 patients hospitalized in 87 neurology units spread over 30 health regions were evaluated retrospectively and prospectively. Results: Intravenous tPA was administered to 12% of 859 cases of acute ischemic stroke in 45 units participating in the study. In the same period, 8.3% of the cases received neurointerventional treatment. The rate of good prognosis [modified Rankin score (mRS) 0–2] at discharge was 46% in 83 patients who received only IV tPA [age: 67 ± 12 years; National Institutes of Health Stroke Scale (NIHSS): 12 ± 6; hospital stay, 24 ± 29 days]; 35% in 51 patients who underwent thrombectomy (MT) alone (age: 64 ± 13 years; NIHSS: 14.1 ± 6.5; length of hospital stay, 33 ± 31 days), 19% in those who received combined treatment (age: 66 ± 14 years; NIHSS: 15.6 ± 5.4; length of hospital stay, 26 ± 35 days), and 56% of 695 patients who did not receive treatment for revascularization (age: 70 ± 13 years; NIHSS: 7.6 ± 7.2; length of hospital stay, 21 ± 28 days). The symptom-to-door time was 87 ± 53 minutes in the IV treatment group and 200 ± 26 minutes in the neurointerventional group. The average door-to-needle time was 66 ± 49 minutes in the IV tPA group. In the neurothrombectomy group, the door-to-groin time was 103 ± 90 minutes, and the TICI 2b-3 rate was 70.3%. In 103 patients who received IV tPA, the discharge mRS 0–2 was 41%, while the rate of mRS 0–1 was 28%. In 71 patients who underwent neurothrombectomy, the mRS 0–2 was 31% and mRS 0–1 was 18%. The door-to-groin time was approximately 30 minutes longer if IV tPA was received (125 ± 107 and 95 ± 83 minutes, respectively). Symptomatic bleeding rates were 4.8% in IV recipients, 17.6% among those who received only MT, and 15% in combined therapy. Globally, the hemorrhage rate was 6.8% in patients receiving IV tPA and 16.9% in MT. Conclusion: IV thrombolytic and neurointerventional treatment applications in acute ischemic stroke in Türkiye can provide the anticipated results. Heterogeneity has begun to be reduced in our country with the dissemination of the system indicated by the “Directive on Health Services to be Provided to Patients with Acute Stroke.”. © Copyright 2023 by the Turkish Neurological Society / Turkish Journal of Neurology published by Galenos Publishing House.
URI: https://doi.org/10.4274/tnd.2023.70292
https://hdl.handle.net/11499/56519
ISSN: 1301-062X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

Page view(s)

82
checked on Aug 24, 2024

Download(s)

30
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.