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https://hdl.handle.net/11499/56672
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gündoğdu, Köksal | - |
dc.contributor.author | Kılınç Erkek, Özgen | - |
dc.contributor.author | Gündogğdu, Gülşah | - |
dc.contributor.author | Sayın, Dilek | - |
dc.contributor.author | Abban Mete, Gülçin | - |
dc.date.accessioned | 2024-02-24T14:31:24Z | - |
dc.date.available | 2024-02-24T14:31:24Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 1715-5312 | - |
dc.identifier.issn | 1715-5320 | - |
dc.identifier.uri | https://doi.org/10.1139/apnm-2023-0377 | - |
dc.identifier.uri | https://hdl.handle.net/11499/56672 | - |
dc.description.abstract | The aim of this study was to assess the effectiveness of combining sericin with swimming exercise as a treatment for type-I collagenase-induced Achilles tendinopathy (AT) in rats, with a focus on inflammatory cytokines. An experimental AT model was established using type-I collagenase in male Sprague-Dawley rats, categorized into five groups: Group 1 (Control + Saline), Group 2 (AT), Group 3 (AT + exercise), Group 4 (AT + sericin), and Group 5 (AT + sericin + exercise). Intratendinous sericin administration (0.8 g/kg/mL) took place from days 3 to 6, coupled with 30 min daily swimming exercise sessions (5 days/week, 4 weeks). Serum samples were analyzed using ELISA for tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-113), interleukin-10 (IL-10), and total antioxidant-oxidant status (TAS-TOS), alongside histopathological and immunohistochemical assessments of Achilles tendon samples. Elevated TNF-alpha and IL-113 and decreased IL-10 levels were evident in Group 2; Of these, TNF-alpha and IL-113 were effectively reduced and IL-10 increased across all treatment groups, particularly groups 4 and 5. Serum TAS was notably lower in Group 2 and significantly increased in Group 5 compared to Group 2. Histopathologically, Group 2 displayed severe degeneration, irregular fibers, and round cell nuclei, while Group 5 exhibited decreased degeneration and spindle-shaped fibers. The Bonar score increased in Group 2 and decreased in groups 4 and 5. Collagen type-I alpha-1 (Col1A1) expression was notably lower in Group 2 (P = 0.001) and significantly increased in groups 4 and 5 compared to Group 2 (P = 0.011 and 0.028, respectively). This study underscores the potential of sericin and swimming exercises in mitigating inflammation and oxidative stress linked to AT pathogenesis, presenting a promising combined therapeutic strategy. | en_US |
dc.description.sponsorship | Pamukkale University Scien-tific Research Projects Unit [2021HZDP001] | en_US |
dc.description.sponsorship | This study was supported by the Pamukkale University Scien-tific Research Projects Unit (project number: 2021HZDP001) . | en_US |
dc.language.iso | en | en_US |
dc.publisher | Canadian Science Publishing | en_US |
dc.relation.ispartof | Applied Physiology Nutrition and Metabolism | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Achilles tendinopathy | en_US |
dc.subject | exercise | en_US |
dc.subject | sericin | en_US |
dc.subject | type-I collagenase | en_US |
dc.subject | Tnf-Alpha | en_US |
dc.subject | Tendon | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Collagen | en_US |
dc.subject | Expression | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Receptor | en_US |
dc.subject | Rupture | en_US |
dc.subject | Disease | en_US |
dc.subject | Protein | en_US |
dc.title | Anti-inflammatory effects of sericin and swimming exercise in treating experimental Achilles tendinopathy in rat | en_US |
dc.type | Article | en_US |
dc.type | Article; Early Access | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | GUNDOGDU, GULSAH/0000-0002-9924-5176 | - |
dc.identifier.doi | 10.1139/apnm-2023-0377 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | GUNDOGDU, GULSAH/A-6982-2018 | - |
dc.identifier.pmid | 38284362 | en_US |
dc.identifier.scopus | 2-s2.0-85189755026 | en_US |
dc.identifier.wos | WOS:001154517800001 | en_US |
dc.institutionauthor | … | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.openairetype | Article; Early Access | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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