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https://hdl.handle.net/11499/56673
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gündoğdu, Gülşah | - |
dc.contributor.author | Yılmaz Tasçı, Şeymanur | - |
dc.contributor.author | Gündoğdu, Köksal | - |
dc.contributor.author | Terim Kapakın, Kübra Asena | - |
dc.contributor.author | Demirkaya, Alper Kürşat | - |
dc.contributor.author | Nalcı, Kemal Alp | - |
dc.contributor.author | Gündoğdu, Mustafa | - |
dc.date.accessioned | 2024-02-24T14:31:24Z | - |
dc.date.available | 2024-02-24T14:31:24Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1715-5312 | - |
dc.identifier.issn | 1715-5320 | - |
dc.identifier.uri | https://doi.org/10.1139/apnm-2021-0801 | - |
dc.identifier.uri | https://hdl.handle.net/11499/56673 | - |
dc.description.abstract | This study aimed to evaluate the effectiveness of omega-3 supplementation with exercise in a collagenase-induced Achilles tendinopathy (AT) rat model. Experimental groups (healthy control (HC), AT, exercise (Ex), omega-3 (W), and Ex+W) were randomly allocated. After a week of adaptation, oral omega-3 was initiated for 8weeks (5 days/week). The exercise groups performed treadmill running for 30min/day (5 days/week, 20m/min, 8 weeks) following one week of adaptation (10 m/min, 15 min/day). Matrix metalloproteinase-13 (MMP-13), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and total antioxidant-oxidant status (TAS) levels were determined in serum samples. Tendon samples were obtained for biomechanical, histopathological, and immunohistochemical assessments. Ultimate tensile force, yield force, stiffness values, collagen type-I alpha 1 expression, and serum TAS significantly decreased (P < 0.05) in AT vs. HC. These values and expression significantly increased in the Ex+W group vs. AT. Serum MMP-13, IL-1 beta, and TNF-alpha levels decreased in all treatment groups vs. AT. The most significant decrease was found in the Ex+W group (P < 0.01). Histopathologically, the improvement in degeneration was statistically significant in the Ex+Wgroup (P < 0.05). Immunohistochemically, MMP-13, IL-1 beta, TNF-alpha, and nitric oxide synthase2 expression was decreased in all treatment groups vs. AT. In conclusion, omega-3 and exercise might be recommended in AT patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Canadian Science Publishing | en_US |
dc.relation.ispartof | Applied Physiology Nutrition and Metabolism | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Achilles tendinopathy | en_US |
dc.subject | exercise | en_US |
dc.subject | omega-3 | en_US |
dc.subject | rat | en_US |
dc.subject | Pro-Inflammatory Cytokines | en_US |
dc.subject | Docosahexaenoic Acid | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Nitric-Oxide | en_US |
dc.subject | Fatty-Acids | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Tendons | en_US |
dc.subject | Modulation | en_US |
dc.subject | Tendinitis | en_US |
dc.subject | Responses | en_US |
dc.title | A combination of omega-3 and exercise reduces experimental Achilles tendinopathy induced with a type-1 collagenase in rats | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 62 | en_US |
dc.identifier.endpage | 73 | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | Abd El-Aty, A. M./0000-0001-6596-7907 | - |
dc.authorid | Gundogdu, Mustafa/0000-0003-2527-0392 | - |
dc.authorid | nalcı, kemal alp/0000-0003-3786-5246 | - |
dc.authorid | YILMAZ TASCI, SEYMANUR/0000-0003-2510-743X | - |
dc.authorid | GUNDOGDU, GULSAH/0000-0002-9924-5176 | - |
dc.identifier.doi | 10.1139/apnm-2021-0801 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Abd El-Aty, A. M./H-8216-2018 | - |
dc.authorwosid | Gundogdu, Mustafa/S-5300-2019 | - |
dc.authorwosid | GUNDOGDU, GULSAH/A-6982-2018 | - |
dc.authorwosid | nalcı, kemal alp/V-7214-2018 | - |
dc.identifier.pmid | 36458821 | en_US |
dc.identifier.wos | WOS:001132689300007 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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