Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56805
Title: Combined surgical and chemotherapy treatment for invasive primary urethral cancer: a case presentation
Authors: Şimşek, Alper
Bütün, Salih
Duran, Mesut Berkan
Küçüker, Kürsat
Çelen, Sinan
Özlulerden, Yusuf
Tuncay, Ömer Levent
Keywords: Primary urethral tumor
Urethroplasty
Urethra
Case report
Case presentation
Prognostic-Factors
Carcinoma
Outcomes
Chemoradiation
Guidelines
Management
Publisher: Springer
Abstract: BackgroundThe European Association of Urology (EAU) defines primary urethral carcinoma (PUC) as a carcinoma that arises in the urethra without a previous diagnosis of carcinoma elsewhere in the urinary system. It is considered as a rare cancer, accounting for less than 1% of all malignant tumors and 5% of malignant tumors of the urinary system. The difficulty in diagnosis and its rarity can lead to delayed diagnosis and decreased survival. We think that a case report to be made in the literature for this rare disease with no consensus on treatment will contribute to disease management.Case presentationIn this article, we describe the diagnosis and treatment process of a 75-year-old patient who was diagnosed with primary urethral cancer and had urethral discharge and difficulty in urination. The biopsy result from the suspected hyperemic area in the urethra in cystourethroscopy was primary urethral cancer. Urethrectomy followed by urethroplasty was performed on the patient's 2-cm primary urethral cancerous tissue. In the postoperative first month, an F-18 FDG whole-body PET scan for oncological evaluation showed increased pathological F-18 FDG uptake in the periphery of the mass in the penile urethra and indistinguishable boundaries from the prostatic urethra. After this, adjuvant gemcitabine and carboplatin therapy was planned by the oncology team.ConclusionsBased on our outcome in this case, we believe that chemotherapy combined with surgery increases the chance of successful treatment in locally advanced urethral cancer.
URI: https://doi.org/10.1186/s12301-024-00413-6
https://hdl.handle.net/11499/56805
ISSN: 1110-5704
1961-9987
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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