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https://hdl.handle.net/11499/5684| Title: | Renal tubular cells undergo apoptosis when exposed to uric acid and calcium oxalate crystals | Authors: | Tuncay, O.L. Gupta, M. Smith, A.D. |
Keywords: | Apoptosis Calcium oxalate Renal tubular cell Uric acid Urinary calculi calcium calcium oxalate oxalic acid animal cell animal experiment animal model animal tissue apoptosis article controlled study crystallization growth disorder interstitium kidney proximal tubule kidney tubule cell kidney tubule epithelium nonhuman opossum stone formation urolithiasis |
Abstract: | Calcium oxalate monohydrate crystals (COMC) and uric acid crystals (UAC) are endocytosed by renal tubular epithelial cells (RTEC). We studied whether these crystals could also induce programmed cell death (apoptosis) which may cause release of endocytosed crystals either into the tubular lumen or into the interstitium. RTEC from the opossum proximal tubule (OK cells) were grown in RPMI media until subconfluent. growth arrested for 48 hours, and incubated with 10 ?gr/ml COMC and 10 ?gr/ml UAC for 24 hours. We concluded that COMC and UAC induce apoptosis of RTEC. This may be of pathogenetic importance not only for interstitial scarring (release into interstitium) but also for crystal growth and stone formation (release into tubular lumen). | URI: | https://hdl.handle.net/11499/5684 | ISSN: | 1300-2996 |
| Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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