Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5684
Title: Renal tubular cells undergo apoptosis when exposed to uric acid and calcium oxalate crystals
Authors: Tuncay, O.L.
Gupta, M.
Smith, A.D.
Keywords: Apoptosis
Calcium oxalate
Renal tubular cell
Uric acid
Urinary calculi
calcium
calcium oxalate
oxalic acid
animal cell
animal experiment
animal model
animal tissue
apoptosis
article
controlled study
crystallization
growth disorder
interstitium
kidney proximal tubule
kidney tubule cell
kidney tubule epithelium
nonhuman
opossum
stone formation
urolithiasis
Abstract: Calcium oxalate monohydrate crystals (COMC) and uric acid crystals (UAC) are endocytosed by renal tubular epithelial cells (RTEC). We studied whether these crystals could also induce programmed cell death (apoptosis) which may cause release of endocytosed crystals either into the tubular lumen or into the interstitium. RTEC from the opossum proximal tubule (OK cells) were grown in RPMI media until subconfluent. growth arrested for 48 hours, and incubated with 10 ?gr/ml COMC and 10 ?gr/ml UAC for 24 hours. We concluded that COMC and UAC induce apoptosis of RTEC. This may be of pathogenetic importance not only for interstitial scarring (release into interstitium) but also for crystal growth and stone formation (release into tubular lumen).
URI: https://hdl.handle.net/11499/5684
ISSN: 1300-2996
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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