Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56874
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dc.contributor.authorÖner, S.Z.-
dc.contributor.authorKaraday, E.-
dc.contributor.authorÇalışkan, A.-
dc.contributor.authorDemir, M.-
dc.contributor.authorŞenol, H.-
dc.contributor.authorKaleli, İ.-
dc.date.accessioned2024-03-23T13:10:02Z-
dc.date.available2024-03-23T13:10:02Z-
dc.date.issued2024-
dc.identifier.issn0255-0857-
dc.identifier.urihttps://doi.org/10.1016/j.ijmmb.2024.100554-
dc.identifier.urihttps://hdl.handle.net/11499/56874-
dc.description.abstractPurpose: The aim of this study was to evaluate the distribution of integrons in strains of E. coli isolated from blood culture and the relationship between integrons and antimicrobial resistance. Methods: The study included 100 E. coli strains sent to the Medical Microbiology Laboratory from different clinics between September 2022 and June 2023. Antibiotic susceptibility was evaluated according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). The presence of integrons was determined by the inhouse polymerase chain reaction (PCR). Results: Integron positivity was detected in 45 (45%) of isolates, and class 1 integrons were found in 41 (41%), class 2 integrons in 2 (2%), and both class 1 integrons and class 2 integrons in 2 (2%). Class 3 integron positivity was not detected. In total, 63 cases of community origin and 37 cases of hospital origin were identified. When antibiotic resistance was evaluated, the highest sensitivity was noted for amikacin (1%), meropenem (5%), imipenem (6%), and the highest resistant antibiotics were ampicillin (82%), cepfuroxime sodium (65%), and amoxicillin/clavulanate (62%), respectively. Of the 16 antimicrobial substances evaluated, 10 had an antibiotic resistance rate of over 45%. In class 1 integron-positive samples, ampicillin resistance and trimethoprim/sulfamethoxazole resistance were higher than in negative samples (p = 0.02, p = 0.0001, respectively). Fifty-one (51%) samples were found to have multiple drug resistance (MDR). In total, 59.5% of hospital-acquired isolates and 46% of community-acquired isolates were considered to be MDR. The class 1 integron positivity in MDR samples was high (p = 0.038). Conclusion: The high MDR rates in both hospital-acquired and community-acquired isolates are alarming. In particular, class 1 integron monitoring is very important to prevent the spread of MDR isolates. © 2024 Indian Association of Medical Microbiologistsen_US
dc.language.isoenen_US
dc.publisherIndian Association of Medical Microbiologistsen_US
dc.relation.ispartofIndian Journal of Medical Microbiologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood cultureen_US
dc.subjectE colien_US
dc.subjectIntegronsen_US
dc.subjectMultiple drug resistanceen_US
dc.titleIntegron distribution and relationship to antimicrobial resistance in E. coli isolated from blood cultureen_US
dc.typeArticleen_US
dc.identifier.volume48en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1016/j.ijmmb.2024.100554-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57196044682-
dc.authorscopusid58925464800-
dc.authorscopusid56727931300-
dc.authorscopusid8657819000-
dc.authorscopusid56345836900-
dc.authorscopusid6508232943-
dc.identifier.pmid38408609en_US
dc.identifier.scopus2-s2.0-85186984315en_US
dc.identifier.wosWOS:001201904700001en_US
dc.institutionauthor-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeArticle-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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