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https://hdl.handle.net/11499/5698| Title: | Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle | Authors: | Altan, N. Yigit, Ş. Elmali, E. Malhatun, E. Rota, Simin Kiliç, N. |
Keywords: | diabetes mellitus Glyburide superoxide dismutase glibenclamide glucose streptozocin sulfonylurea derivative animal model animal tissue article controlled study drug effect enzyme activity glucose blood level male muscle nonhuman oral drug administration priority journal rat streptozocin diabetes Animals Blood Glucose Body Weight Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 Hypoglycemic Agents Male Muscle, Skeletal Rats Superoxide Dismutase |
Abstract: | 1. The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulinlike effects on muscle SOD activity in vivo. | URI: | https://hdl.handle.net/11499/5698 https://doi.org/10.1016/S0306-3623(96)00355-2 |
ISSN: | 0306-3623 |
| Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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