Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56980
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dc.contributor.authorAlayvaz Aslan, Nevin-
dc.contributor.authorAvcı, Esin-
dc.contributor.authorŞenol, Hande-
dc.contributor.authorGueler, Nil-
dc.date.accessioned2024-05-06T16:24:33Z-
dc.date.available2024-05-06T16:24:33Z-
dc.date.issued2024-
dc.identifier.issn1081-5589-
dc.identifier.issn1708-8267-
dc.identifier.urihttps://doi.org/10.1177/10815589241238218-
dc.identifier.urihttps://hdl.handle.net/11499/56980-
dc.description.abstractAcute myeloid leukemia (AML) is a hematologic malignancy characterized by the proliferation of CD34 positive self-renewing malignant hematopoietic stem cells. Previous studies have shown that the transforming growth factor beta (TGF beta) pathway plays a role in AML pathogenesis, especially by affecting the microenvironment. Growth differentiation factor 11 (GDF11) is a member of the TGF beta superfamily, involved in embryological development and known as rejuvenating factor. In this study, our aim was to determine the serum GDF11 level in patients with AML, to compare it with the control group, to determine its relationship with follistatin, vimentin, and E-cadherin levels, and to determine whether GDF11 influences AML prognosis. Serum GDF11, vimentin, follistatin, and E-cadherin levels of newly diagnosed or relapsed/refractory AML patients and age- and gender-matched control group were measured by enzyme-linked immunosorbent assay. Serum GDF11 level was higher in the patient group (263.87 +/- 126.54 ng/L) compared to the control group (211.54 +/- 61.47 ng/L; p = 0.035). GDF11 level did not change according to age, gender, hemoglobin level, and bone marrow blast rate. No correlation was found between GDF11 level, response rates, and survival status of the patients. A positive correlation was detected between GDF11, E-cadherin, and vimentin levels. As a conclusion, increased serum GDF11 levels in AML patients may be linked to the regeneration ability of leukemic stem cells. There is a need for studies investigating GDF11 expression in myeloblasts.en_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute myeloid leukemiaen_US
dc.subjectGDF-11en_US
dc.subjectE-cadherinen_US
dc.subjectvimentinen_US
dc.subjectrejuvenationen_US
dc.subjectDifferentiation Factor 11en_US
dc.subjectGrowthen_US
dc.subjectErythropoiesisen_US
dc.subjectLuspatercepten_US
dc.subjectActivinen_US
dc.titleGDF11 level and its effect on prognosis in patients with acute myeloid leukemiaen_US
dc.typeArticleen_US
dc.identifier.volume72en_US
dc.identifier.issue4en_US
dc.identifier.startpage341en_US
dc.identifier.endpage348en_US
dc.departmentPamukkale Universityen_US
dc.authoridGuler, Nil/0000-0003-0604-6475-
dc.identifier.doi10.1177/10815589241238218-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56895869600-
dc.authorscopusid57209468091-
dc.authorscopusid56345836900-
dc.authorscopusid9044339200-
dc.authorwosidGuler, Nil/ABE-4485-2021-
dc.identifier.pmid38415361en_US
dc.identifier.scopus2-s2.0-85189816285en_US
dc.identifier.wosWOS:001196750300007en_US
dc.institutionauthor-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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