Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/56994
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DC Field | Value | Language |
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dc.contributor.author | Kahraman, Seda | - |
dc.contributor.author | Karakaya, Serdar | - |
dc.contributor.author | Kaplan, Muhammed Ali | - |
dc.contributor.author | Sezgin Göksu, Sema | - |
dc.contributor.author | Özturk, Akın | - |
dc.contributor.author | Sucuoğlu İşleyen, Zehra | - |
dc.contributor.author | Hamdard, Jamshid | - |
dc.contributor.author | Yildirim, Sedat | - |
dc.contributor.author | Dogan, Tolga | - |
dc.contributor.author | Isik, Selver | - |
dc.contributor.author | Celebi, Abdussamet | - |
dc.contributor.author | Gulbagci, Burcu Belen | - |
dc.contributor.author | Paksoy, Nail | - |
dc.contributor.author | Dogan, Mutlu | - |
dc.contributor.author | Turk, Haci Mehmet | - |
dc.contributor.author | Bilici, Ahmet | - |
dc.contributor.author | Tatli, Ali Murat | - |
dc.contributor.author | Akbas, Sinem | - |
dc.contributor.author | Turan, Nedim | - |
dc.contributor.author | Hacibekiroglu, Ilhan | - |
dc.contributor.author | Dogu, Gamze Gokoz | - |
dc.contributor.author | Aydiner, Adnan | - |
dc.contributor.author | Sumbul, Ahmet Taner | - |
dc.contributor.author | Akyurek, Serap | - |
dc.contributor.author | Yalciner, Merih | - |
dc.contributor.author | Demirkazik, Ahmet | - |
dc.contributor.author | Gursoy, Pinar | - |
dc.contributor.author | Aykan, Musa Baris | - |
dc.contributor.author | Sahin, Elif | - |
dc.contributor.author | Karadag, İbrahim | - |
dc.contributor.author | Kostek, Osman | - |
dc.contributor.author | Er, Muhammed Muhiddin | - |
dc.contributor.author | Artaç, Mehmet | - |
dc.contributor.author | Duzkopru, Yakup | - |
dc.contributor.author | Aydin, Dincer | - |
dc.contributor.author | Isik, Deniz | - |
dc.contributor.author | Karakas, Yusuf | - |
dc.contributor.author | Kilickap, Saadettin | - |
dc.contributor.author | Erol, Cihan | - |
dc.contributor.author | Demir, Bilgin | - |
dc.contributor.author | Civelek, Burak | - |
dc.contributor.author | Ergun, Yakup | - |
dc.contributor.author | Akinci, Muhammed Bulent | - |
dc.contributor.author | Dogan, Izzet | - |
dc.contributor.author | Karadurmus, Nuri | - |
dc.contributor.author | Yumuk, Perran Fulden | - |
dc.contributor.author | Sendur, Mehmet Ali Nahit | - |
dc.date.accessioned | 2024-05-06T16:24:36Z | - |
dc.date.available | 2024-05-06T16:24:36Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://doi.org/10.1038/s41598-024-56046-w | - |
dc.identifier.uri | https://hdl.handle.net/11499/56994 | - |
dc.description.abstract | Central nervous system (CNS) metastases can be seen at a rate of 30% in advanced stages for patients with non-small cell lung cancer (NSCLC). Growing evidence indicates the predictive roles of driver gene mutations in the development of brain metastases (BM) in recent years, meaning that oncogene-driven NSCLC have a high incidence of BM at diagnosis. Today, 3rd generation targeted drugs with high intracranial efficacy, which can cross the blood-brain barrier, have made a positive contribution to survival for these patients with an increased propensity to BM. It is important to update the clinical and pathological factors reflected in the survival with real-life data. A multi-center, retrospective database of 306 patients diagnosed with driver mutant NSCLC and initially presented with BM between between November 2008 and September 2022 were analyzed. The median progression-free survival (mPFS) was 12.25 months (95% CI, 10-14.5). While 254 of the patients received tyrosine kinase inhibitor (TKI), 51 patients received chemotherapy as first line treatment. The median intracranial PFS (iPFS) was 18.5 months (95% CI, 14.8-22.2). The median overall survival (OS) was 29 months (95% CI, 25.2-33.0). It was found that having 3 or less BM and absence of extracranial metastases were significantly associated with better mOS and iPFS. The relationship between the size of BM and survival was found to be non-significant. Among patients with advanced NSCLC with de novo BM carrying a driver mutation, long-term progression-free and overall survival can be achieved with the advent of targeted agents with high CNS efficacy with more conservative and localized radiotherapy modalities. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Portfolio | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Oncogene-driven advanced non-small cell lung cancer | en_US |
dc.subject | De novo brain metastases | en_US |
dc.subject | Survival related parameters | en_US |
dc.subject | Open-Label | en_US |
dc.subject | Alk | en_US |
dc.subject | Multicenter | en_US |
dc.title | Treatment outcomes and prognostic factors in patients with driver mutant non-small cell lung cancer and de novo brain metastases | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 1 | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | Paksoy, Nail/0000-0003-4636-2595 | - |
dc.authorid | kahraman, seda/0000-0002-5328-6554 | - |
dc.authorid | Doğan, İzzet/0000-0003-1018-1119 | - |
dc.authorid | Sahin, Elif/0000-0002-1976-3951 | - |
dc.identifier.doi | 10.1038/s41598-024-56046-w | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56960020000 | - |
dc.authorscopusid | 57033928400 | - |
dc.authorscopusid | 57243378400 | - |
dc.authorscopusid | 23018424300 | - |
dc.authorscopusid | 57209520898 | - |
dc.authorscopusid | 57944011800 | - |
dc.authorscopusid | 56449214500 | - |
dc.authorwosid | Paksoy, Nail/HKF-3015-2023 | - |
dc.authorwosid | kahraman, seda/KHU-2244-2024 | - |
dc.authorwosid | Doğan, İzzet/AAB-6635-2020 | - |
dc.identifier.pmid | 38461209 | en_US |
dc.identifier.scopus | 2-s2.0-85187188671 | en_US |
dc.identifier.wos | WOS:001185505600041 | en_US |
dc.institutionauthor | … | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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