Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56996
Title: Evaluation of cardiac functions in children with familial Mediterranean fever
Authors: Arslan, Sema Yildirim
Gurses, Dolunay
Yüksel, Selçuk
Keywords: Aortic stiffness
familial Mediterranean fever
heart rate variability
MEFV gene
QT dispersion
tissue Doppler echocardiography
Arterial Elastic Properties
Heart-Rate-Variability
Left-Ventricular Mass
Tissue Doppler
Qt Dispersion
Rate Recovery
Colchicine
Stiffness
Disease
Echocardiography
Publisher: Cambridge Univ Press
Abstract: Objectives: Familial Mediterranean fever is an autosomal recessive autoinflammatory inherited disease. We aimed to evaluate cardiac involvement in children with familial Mediterranean fever during the attack-free period. Material and Methods: The prospective study included 75 familial Mediterranean fever patients during the attack-free period and 50 healthy children. Cardiac evaluation was performed using electrocardiography, 24-hour ambulatory Holter monitoring, and conventional and tissue Doppler echocardiography. Aortic stiffness indices were calculated. Results: There were no differences between the groups in age, height, sex, body mass index, and arterial blood pressure parameters (p > 0.05). QT and corrected QT dispersion parameters were similar in both groups (p > 0.05). The E wave velocity and the E/A ratio of the mitral and tricuspid valves decreased, and the A wave velocity of the tricuspid and mitral valve increased in familial Mediterranean fever by the Doppler echocardiography (p < 0.05). The myocardial contraction velocities (Sd), early relaxation velocity (Ed), and Ed/late relaxation velocity (Ad) of both ventricles were decreased in familial Mediterranean fever group, whereas the Ad of both ventricles and the interventricular septum was increased in familial Mediterranean fever group. Aortic strain and distensibility were decreased, and pressure strain elastic modules (Ep), pressure strain normalised (Ep*) by diastolic pressure, and aortic stiffness beta index were increased in familial Mediterranean fever patients (p < 0.05). When time domain heart rate variability parameters were evaluated, SDNN-i, RMSSD, and PNN50 significantly decreased in familial Mediterranean fever patients (p < 0.05), whereas SDNN and SDANN were similar in both groups (p > 0.05). Conclusion: Our findings showed that cardiac involvement could exist in familial Mediterranean fever patients, even during nonattack periods.
URI: https://doi.org/10.1017/S1047951124000787
https://hdl.handle.net/11499/56996
ISSN: 1047-9511
1467-1107
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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