Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5729
Title: Applying critical pressure to middle cerebral artery in dogs
Authors: Tahta, K.
Ozgen, T.
Aras, T.
Topcu, M.
Erol, U.
Keywords: dogs
middle cerebral artery
animal experiment
article
brain blood flow
brain ischemia
controlled study
dog
middle cerebral artery occlusion
nonhuman
Animals
Blood Pressure
Brain
Cerebral Arteries
Cerebrovascular Circulation
Dissection
Dogs
Evoked Potentials, Somatosensory
Microscopy, Electron
Abstract: The purpose of our model was to provide maximum pressure level of the middle cerebral artery (MCA) without causing any histological variation like focal cerebral ischaemia. In this experimental study 9 dogs were used. A modified Spetzler occluder was applied to the MCA of the dogs to determine regional cerebral blood flow (rCBF) and somatosensory evoked potentials (SSEP). Seven animals underwent the surgical procedure with measurements of rCBF after arterial microdissection and then after applying 80% blood pressure (BP) to the MCA for 15 minutes. In rCBF a 29% average reduction was observed. The average value of rCBF at the end of 15 minutes was 63.5 ± 6.52 ml/100 g min. Simultaneous somatosensory evoked potential recordings were also obtained. When rCBF was reduced 29%, 80% BP applying to MCA did not cause complications.
URI: https://hdl.handle.net/11499/5729
ISSN: 0026-4881
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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