Determining the levels of serum Heat Shock Protein B7 (HSPB7) and tetranectin in patients undergoing hemodialysis

Abstract

Purpose: Heart damage may develop over time in patients with chronic renal disease (CKD), who are undergoing hemodialysis (HD) treatment. Serum levels of heat shock protein B7 (HSPB7) and tetranectin proteins change following damage to the heart muscle. This study aimed to determine HSPB7 and tetranectin levels in patients with CKD undergoing HD treatment. Materials and methods: The patients aged 30-60 years old, healthy controls (n=30) and HD patients (n=30) participated in the study. Blood samples were taken from healthy subjects who applied to the hospital for check-up and from patients with kidney disease receiving HD treatment. Biochemical parameters were examined from the blood taken. HSPB7 and tetranectin levels from isolated serum samples were determined using measurement kits based on the solid phase sandwich (ELISA) principle. Results: There was no significant difference between the groups in gender, age, glucose and iron (Fe) values of the subjects (p>0.05). Lymphocyte, platelet counts, hemoglobin and albumin values were found to be lower in patient group compared to the control group (p<0.05). Urea, creatine kinase (CK) and C-reactive protein (CRP) values were found to be higher in patient group than in the control group (p<0.05). A significant increase in HSPB7 levels and a significant decrease in tetranectin levels were detected in patient group compared to control group (p<0.001). Conclusions: In this study, the changes detected in HSPB7 and tetranectin levels in with CKD undergoing HD treatment. May be early indicators of the possible development of cardiovascular diseases in patients with renal disease. © 2024, Pamukkale University. All rights reserved.