Evaluation of extradural morphine, fentanyl and i.m. dipyron in the postoperative analgesia

Abstract

Postoperative analgesia that was provided by extradural administration of morphine, fentanyl or i.m. dipyron in 52 patients was discussed in a randomized study. Patients were randomly assigned into three groups to receive either extradural morphine (4 mg), fentanyl (100 mg) or intramuscular dipyron (1 g). Morphine (4 mg) in 10 ml saline solution was used in group I (19 patients), fentanyl (100 mg) in group II (19 patients) and dipyron (i.m. 1 g) in group III (14 patients). Pain and sedation analogue score, side effects, cardiovascular and respiratory effects, quality and duration of pain relief were recorded. The analogue pain scores were decreased significantly by morphine and fentanyl (p<0.001), but there were no significant differences by dipyron (p>0.05). The duration of analgesia with morphine, fentanyl and dipyron were respectively 19, 2.1 and 3.7 hours. The quality of pain relief was better by morphine and side effects were neglectible.