Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57466
Title: Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours—results from a Turkish multi-centre study
Authors: Olmez, O.F.
Bilici, A.
Er, O.
Bisgin, A.
Sevinc, A.
Akman, T.
Uslu, R.
Mandel, Nil Molinas
Yalcin, Suayib
Teomete, Mehmet
Gorumlu, Gurbuz
Demir, Atakan
Namal, Esat
Alici, Suleyman
Selcukbiricik, Fatih
Bavbek, Sevil
Paksoy, Fatma
Basaran, Gul
Ozer, Leyla
Sener, Nur
Harputluoglu, Hakan
Kaya, Ali Osman
Yazar, Aziz
Afsar, Cigdem Usul
Goker, Erdem
Sen, Fatma
Dogu, Gamze Gokoz
Şeker, Mesut
Ozkan, Metin
Turken, Orhan
Ozveren, Ahmet
Orhan, Bulent
Yumuk, Fulden
Uskent, Necdet
Saip, Pınar
Anlı, Ulus Ali
Disel, Umut
Berk, Veli
Alakavuklar, Mehmet
Keywords: advanced solid tumours
complex molecular profiling
next-generation sequencing
therapeutic planning
treatment response
biological marker
tumor marker
adenoid cystic carcinoma
adjuvant therapy
adult
advanced cancer
aged
Article
benign nasal tumor
bladder cancer
brain cancer
breast cancer
cancer chemotherapy
clinical significance
cohort analysis
cost effectiveness analysis
DNA extraction
ECOG Performance Status
endocrine cancer
endometrium cancer
female
gastrointestinal cancer
gastrointestinal stromal tumor
gene mutation
glioblastoma
head and neck cancer
high throughput sequencing
human
lung cancer
major clinical study
male
metastasis
molecular fingerprinting
mutational analysis
neoadjuvant therapy
outcome assessment
ovary cancer
physical activity
prevalence
quality of life
renal cell carcinoma
sarcoma
solid malignant neoplasm
traditional medicine
transurethral resection
treatment response
uterine cervix cancer
clinical significance
clinical trial
gene expression profiling
genetics
middle aged
multicenter study
neoplasm
pathology
personalized medicine
treatment outcome
turkey (bird)
Adult
Aged
Biomarkers, Tumor
Clinical Relevance
Female
Gene Expression Profiling
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Neoplasms
Precision Medicine
Treatment Outcome
Turkey
Publisher: Oxford University Press
Abstract: Objective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes. Methods: The study encompassed 234 adult patients (mean age: 52.7 ± 14.3 years, 54.7% women) who were diagnosed with solid tumours at 21 different medical centres in Turkey. Remarkably, 67.9% of the patients exhibited metastasis at the time of diagnosis. We utilized an OncoDNA (Gosselies, Belgium) platform (OncoDEEP) integrating next-generation sequencing with additional tests to harvest complex molecular profiling data. The results were analyzed in relation with two specific outcomes: (i) the impact on therapeutic decisions, including formulation or modifications, and (ii) associated treatment response. Results: Out of the 228 patients with final molecular profiling results, 118 (50.4%) had their treatment modified, whilst the remaining 110 (47.0%) did not. The response rates were comparable, with 3.9 versus 3.4% for complete response, 13.6 versus 29.3% for partial response, 66.9 versus 51.7% for progressive disease and 15.5 versus 15.5% for stable disease for treatments informed and not informed by complex molecular profiling, respectively (P = 0.16). Conclusion: Our real-world findings highlight the significant impact of complex molecular profiling on the treatment decisions made by oncologists for a substantial portion of patients with advanced solid tumours. Regrettably, no significant advantage was detected in terms of treatment response or disease control rates. © The Author(s) 2024. Published by Oxford University Press. All rights reserved.
URI: https://doi.org/10.1093/jjco/hyae002
https://hdl.handle.net/11499/57466
ISSN: 0368-2811
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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