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Title: | Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours—results from a Turkish multi-centre study | Authors: | Olmez, O.F. Bilici, A. Er, O. Bisgin, A. Sevinc, A. Akman, T. Uslu, R. Mandel, Nil Molinas Yalcin, Suayib Teomete, Mehmet Gorumlu, Gurbuz Demir, Atakan Namal, Esat Alici, Suleyman Selcukbiricik, Fatih Bavbek, Sevil Paksoy, Fatma Basaran, Gul Ozer, Leyla Sener, Nur Harputluoglu, Hakan Kaya, Ali Osman Yazar, Aziz Afsar, Cigdem Usul Goker, Erdem Sen, Fatma Dogu, Gamze Gokoz Şeker, Mesut Ozkan, Metin Turken, Orhan Ozveren, Ahmet Orhan, Bulent Yumuk, Fulden Uskent, Necdet Saip, Pınar Anlı, Ulus Ali Disel, Umut Berk, Veli Alakavuklar, Mehmet |
Keywords: | advanced solid tumours complex molecular profiling next-generation sequencing therapeutic planning treatment response biological marker tumor marker adenoid cystic carcinoma adjuvant therapy adult advanced cancer aged Article benign nasal tumor bladder cancer brain cancer breast cancer cancer chemotherapy clinical significance cohort analysis cost effectiveness analysis DNA extraction ECOG Performance Status endocrine cancer endometrium cancer female gastrointestinal cancer gastrointestinal stromal tumor gene mutation glioblastoma head and neck cancer high throughput sequencing human lung cancer major clinical study male metastasis molecular fingerprinting mutational analysis neoadjuvant therapy outcome assessment ovary cancer physical activity prevalence quality of life renal cell carcinoma sarcoma solid malignant neoplasm traditional medicine transurethral resection treatment response uterine cervix cancer clinical significance clinical trial gene expression profiling genetics middle aged multicenter study neoplasm pathology personalized medicine treatment outcome turkey (bird) Adult Aged Biomarkers, Tumor Clinical Relevance Female Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Male Middle Aged Neoplasms Precision Medicine Treatment Outcome Turkey |
Publisher: | Oxford University Press | Abstract: | Objective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes. Methods: The study encompassed 234 adult patients (mean age: 52.7 ± 14.3 years, 54.7% women) who were diagnosed with solid tumours at 21 different medical centres in Turkey. Remarkably, 67.9% of the patients exhibited metastasis at the time of diagnosis. We utilized an OncoDNA (Gosselies, Belgium) platform (OncoDEEP) integrating next-generation sequencing with additional tests to harvest complex molecular profiling data. The results were analyzed in relation with two specific outcomes: (i) the impact on therapeutic decisions, including formulation or modifications, and (ii) associated treatment response. Results: Out of the 228 patients with final molecular profiling results, 118 (50.4%) had their treatment modified, whilst the remaining 110 (47.0%) did not. The response rates were comparable, with 3.9 versus 3.4% for complete response, 13.6 versus 29.3% for partial response, 66.9 versus 51.7% for progressive disease and 15.5 versus 15.5% for stable disease for treatments informed and not informed by complex molecular profiling, respectively (P = 0.16). Conclusion: Our real-world findings highlight the significant impact of complex molecular profiling on the treatment decisions made by oncologists for a substantial portion of patients with advanced solid tumours. Regrettably, no significant advantage was detected in terms of treatment response or disease control rates. © The Author(s) 2024. Published by Oxford University Press. All rights reserved. | URI: | https://doi.org/10.1093/jjco/hyae002 https://hdl.handle.net/11499/57466 |
ISSN: | 0368-2811 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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