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https://hdl.handle.net/11499/57471
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DC Field | Value | Language |
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dc.contributor.author | Uğraş, Z. | - |
dc.contributor.author | Tok, F. | - |
dc.contributor.author | Çakir, C. | - |
dc.contributor.author | Tuna, K. | - |
dc.contributor.author | Tatar-Yilmaz, G. | - |
dc.contributor.author | Mutlu, D. | - |
dc.contributor.author | Sicak, Y. | - |
dc.contributor.author | Arslan, Şevki | - |
dc.contributor.author | Öztürk, Mehmet | - |
dc.contributor.author | Koçyіğіt-Kaymakçioğlu, Bedia | - |
dc.date.accessioned | 2024-06-29T13:49:57Z | - |
dc.date.available | 2024-06-29T13:49:57Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 0022-2860 | - |
dc.identifier.uri | https://doi.org/10.1016/j.molstruc.2024.138978 | - |
dc.identifier.uri | https://hdl.handle.net/11499/57471 | - |
dc.description.abstract | Herein, unique pyrazoline derivatives were synthesized, and their structures were elucidated by various spectroscopic techniques. Moreover, potential in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, and α-amylase inhibition effects of the compounds were also investigated. Molecular docking studies were performed to further elucidate the enzyme inhibitory activities. The compound 2c (IC50 = 1.64±0.04 and 4.18±0.22 µM, respectively) exhibited the strongest inhibitory activity against AChE and BChE, while compounds 2 m (IC50 = 4.29±0.20 µM) and 2i (IC50 = 4.31±0.08 µM) showed promising AChE inhibitory activity. On the other hand, compounds 2a (IC50= 5.01±0.13 µM) and 2i (IC50 = 5.06±0.72 µM) significantly inhibited BChE. In addition, all compounds except 2c and 2f showed great inhibitory activity against α-amylase at lower concentrations compared to acarbose (IC50 = 72.57 ± 3.16 µM). Similarly, all compounds except 2k exhibited higher inhibitory activity than acarbose (IC50 = 207.08±12.20 µM) against α-glucosidase. Among the compounds, 2a (IC50 = 15.05±5.64 µM), 2b (IC50 = 14.34±5.05 µM), and 2e (IC50 = 11.72±0.46 µM) had excellent inhibitory activity at certain concentrations. The data obtained from the molecular docking studies supported inhibitory activity results. This study presents potential leads for the development of antidiabetic and Alzheimer's therapeutics. © 2024 | en_US |
dc.description.sponsorship | Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 221S850 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Journal of Molecular Structure | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 2-pyrazoline | en_US |
dc.subject | Alzheimer | en_US |
dc.subject | Antidiabetic | en_US |
dc.subject | Docking | en_US |
dc.subject | Synthesis | en_US |
dc.subject | Molecular modeling | en_US |
dc.subject | 2-pyrazolines | en_US |
dc.subject | Acetylcholinesterase | en_US |
dc.subject | Alzheimer | en_US |
dc.subject | Antidiabetic | en_US |
dc.subject | Butyrylcholinesterase | en_US |
dc.subject | Docking | en_US |
dc.subject | Docking studies | en_US |
dc.subject | Inhibitory activity | en_US |
dc.subject | Molecular docking | en_US |
dc.subject | Pyrazoline derivative | en_US |
dc.subject | Amylases | en_US |
dc.title | Exploring 2-Pyrazoline derivatives as potent antidiabetic agents and cholinesterase inhibitors: Their synthesis and molecular docking studies | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 1315 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1016/j.molstruc.2024.138978 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57224798791 | - |
dc.authorscopusid | 57189214206 | - |
dc.authorscopusid | 55990068000 | - |
dc.authorscopusid | 57208945522 | - |
dc.authorscopusid | 57190610518 | - |
dc.authorscopusid | 57212511655 | - |
dc.authorscopusid | 57189295279 | - |
dc.identifier.scopus | 2-s2.0-85195860102 | en_US |
dc.identifier.wos | WOS:001257723000001 | en_US |
dc.institutionauthor | … | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
crisitem.author.dept | 17.02. Biology | - |
crisitem.author.dept | 29.07. Medical Services and Techniques | - |
Appears in Collections: | Fen Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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