Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57471
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dc.contributor.authorUğraş, Z.-
dc.contributor.authorTok, F.-
dc.contributor.authorÇakir, C.-
dc.contributor.authorTuna, K.-
dc.contributor.authorTatar-Yilmaz, G.-
dc.contributor.authorMutlu, D.-
dc.contributor.authorSicak, Y.-
dc.contributor.authorArslan, Şevki-
dc.contributor.authorÖztürk, Mehmet-
dc.contributor.authorKoçyіğіt-Kaymakçioğlu, Bedia-
dc.date.accessioned2024-06-29T13:49:57Z-
dc.date.available2024-06-29T13:49:57Z-
dc.date.issued2024-
dc.identifier.issn0022-2860-
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2024.138978-
dc.identifier.urihttps://hdl.handle.net/11499/57471-
dc.description.abstractHerein, unique pyrazoline derivatives were synthesized, and their structures were elucidated by various spectroscopic techniques. Moreover, potential in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, and α-amylase inhibition effects of the compounds were also investigated. Molecular docking studies were performed to further elucidate the enzyme inhibitory activities. The compound 2c (IC50 = 1.64±0.04 and 4.18±0.22 µM, respectively) exhibited the strongest inhibitory activity against AChE and BChE, while compounds 2 m (IC50 = 4.29±0.20 µM) and 2i (IC50 = 4.31±0.08 µM) showed promising AChE inhibitory activity. On the other hand, compounds 2a (IC50= 5.01±0.13 µM) and 2i (IC50 = 5.06±0.72 µM) significantly inhibited BChE. In addition, all compounds except 2c and 2f showed great inhibitory activity against α-amylase at lower concentrations compared to acarbose (IC50 = 72.57 ± 3.16 µM). Similarly, all compounds except 2k exhibited higher inhibitory activity than acarbose (IC50 = 207.08±12.20 µM) against α-glucosidase. Among the compounds, 2a (IC50 = 15.05±5.64 µM), 2b (IC50 = 14.34±5.05 µM), and 2e (IC50 = 11.72±0.46 µM) had excellent inhibitory activity at certain concentrations. The data obtained from the molecular docking studies supported inhibitory activity results. This study presents potential leads for the development of antidiabetic and Alzheimer's therapeutics. © 2024en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 221S850en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-pyrazolineen_US
dc.subjectAlzheimeren_US
dc.subjectAntidiabeticen_US
dc.subjectDockingen_US
dc.subjectSynthesisen_US
dc.subjectMolecular modelingen_US
dc.subject2-pyrazolinesen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAlzheimeren_US
dc.subjectAntidiabeticen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectDockingen_US
dc.subjectDocking studiesen_US
dc.subjectInhibitory activityen_US
dc.subjectMolecular dockingen_US
dc.subjectPyrazoline derivativeen_US
dc.subjectAmylasesen_US
dc.titleExploring 2-Pyrazoline derivatives as potent antidiabetic agents and cholinesterase inhibitors: Their synthesis and molecular docking studiesen_US
dc.typeArticleen_US
dc.identifier.volume1315en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1016/j.molstruc.2024.138978-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57224798791-
dc.authorscopusid57189214206-
dc.authorscopusid55990068000-
dc.authorscopusid57208945522-
dc.authorscopusid57190610518-
dc.authorscopusid57212511655-
dc.authorscopusid57189295279-
dc.identifier.scopus2-s2.0-85195860102en_US
dc.identifier.wosWOS:001257723000001en_US
dc.institutionauthor-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept17.02. Biology-
crisitem.author.dept29.07. Medical Services and Techniques-
Appears in Collections:Fen Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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