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https://hdl.handle.net/11499/57560
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DC Field | Value | Language |
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dc.contributor.author | Şahbudak Bal, Zümrüt | - |
dc.contributor.author | Arslan, Sema Yıldırım | - |
dc.contributor.author | Güner Özenen, Gizem | - |
dc.contributor.author | Okur, Dicle Şener | - |
dc.contributor.author | Kılıçaslan, Önder | - |
dc.contributor.author | Demirbuğa, Asuman | - |
dc.contributor.author | Turgut, Elif Afat | - |
dc.contributor.author | Dalgic, Nazan | - |
dc.contributor.author | Belet, Nursen | - |
dc.contributor.author | Inceli, Hatice Belkis | - |
dc.contributor.author | Elvan-Tuz, Aysegul | - |
dc.contributor.author | Kara, Tugce Tural | - |
dc.contributor.author | Bulbul, Beyhan | - |
dc.contributor.author | Demirdag, Tugba | - |
dc.contributor.author | Cakici, Ozlem | - |
dc.contributor.author | Bal, Alkan | - |
dc.contributor.author | Ergun, Deniz | - |
dc.contributor.author | Altug, Umut | - |
dc.contributor.author | Arslan, Asli | - |
dc.contributor.author | Isancli, Didem Kizmaz | - |
dc.contributor.author | Torun, Selda Hancerli | - |
dc.contributor.author | Celik, Umit | - |
dc.contributor.author | Yasar, Belma | - |
dc.contributor.author | Erbas, Irem Ceren | - |
dc.contributor.author | Oncel, Eda Karadag | - |
dc.contributor.author | Akbas, Ali | - |
dc.contributor.author | Gudeloglu, Elif | - |
dc.contributor.author | Sen, Semra | - |
dc.contributor.author | Kacar, Pelin | - |
dc.contributor.author | Dede, Elif | - |
dc.contributor.author | Petmezci, Ercument | - |
dc.contributor.author | Aksoy, Fatma Dilsad | - |
dc.contributor.author | Karbuz, Adem | - |
dc.contributor.author | Oncel, Selim | - |
dc.contributor.author | Tezer, Hasan | - |
dc.contributor.author | Devrim, Ilker | - |
dc.contributor.author | Ciftci, Ergin | - |
dc.contributor.author | Hacimustafaoglu, Mustafa | - |
dc.contributor.author | Kurugol, Zafer | - |
dc.date.accessioned | 2024-07-28T17:16:00Z | - |
dc.date.available | 2024-07-28T17:16:00Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2168-8184 | - |
dc.identifier.uri | https://doi.org/10.7759/cureus.60940 | - |
dc.identifier.uri | https://hdl.handle.net/11499/57560 | - |
dc.description.abstract | Background Vaccines have the most important role in the battle against the COVID-19 pandemic. With the widespread use of vaccines, COVID-19 has remarkably declined. Adolescents were vaccinated after approvals for this age group, which was later than adults, and a nationwide vaccination program was implemented in August 2021 in Turkey for adolescents >= 12 years of age. Therefore, we aimed to determine the effects of the COVID-19 nationwide adolescent vaccination program on adolescent hospitalizations due to COVID-19 and multisystem inflammatory syndrome in children (MIS-C) by comparing two periods, including the vaccination period (VP) and the pre-VP (PVP). The second aim of this study is to compare the clinical features and disease severity of vaccine-breakthrough COVID-19 hospitalizations with unvaccinated individuals in the VP. Methods A retrospective multicenter study was conducted to determine and compare the number of hospitalizations due to COVID-19 and MIS-C between the VP (September 1, 2021, to August 31, 2022) and PVP (September 1, 2020, to August 31, 2021). We also compared the characteristics, risk factors, and outcomes of breakthrough infections of adolescents aged 12-18, which required hospitalization with the same age group of unvaccinated hospitalized individuals during the VP. Results During the study period, 3967 children (0-18 years) were hospitalized in the PVP and 5143 (0-18 years) in the VP. Of them, 35.4% were adolescents (12-18 years) in the PVP, and this rate was 18.6% in the VP; relative risk was 0.6467 (95% confidence interval [CI]: 0.6058-0.6904; p < 0.001). Patients with breakthrough COVID- 19 were older (201 vs. 175 months, p < 0.001) and less commonly hospitalized for COVID-19 (81.5% vs. 60.4%, p < 0.001, odds ratio [OR]: 0.347 [95% CI: 0.184-0.654]). The majority of these infections were asymptomatic and mild (32% vs.72.9%: p < 0.001, OR: 5.718 [95% CI: 2.920-11.200]), and PICU admission was less frequently required (p = 0.011, OR: 0.188 [95% CI: 0.045-0.793]). Most breakthrough COVID-19 infections occurred within three months after the last vaccine dose (54.2%). Conclusions This study demonstrated a significant decrease in adolescent hospitalizations due to COVID-19 and MIS -C after implementing COVID-19 vaccines in Turkey. Breakthrough cases were less severe and mostly occurred three months after the last dose. This study emphasizes the importance of COVID-19 vaccines and that parents' decisions may be changed, particularly those who hesitate to or refuse vaccination. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springernature | en_US |
dc.relation.ispartof | Cureus Journal of Medical Science | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | hospitalization in covid-19 | en_US |
dc.subject | adolescent | en_US |
dc.subject | covid-19 | en_US |
dc.subject | sars-cov-2 | en_US |
dc.subject | vaccine breakthrough infection | en_US |
dc.subject | Sars-Cov-2 Infection | en_US |
dc.title | Adolescents With Breakthrough COVID-19 Infections Requiring Hospitalization: A Multicenter Retrospective Study | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 5 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.7759/cureus.60940 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 38915988 | en_US |
dc.identifier.wos | WOS:001250408900028 | en_US |
dc.institutionauthor | … | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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cureus-0016-00000060940.pdf | 286.41 kB | Adobe PDF | View/Open |
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