Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57571
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dc.contributor.authorHepokur, Ceylan-
dc.contributor.authorMısır, Sema-
dc.contributor.authorÇiçek, Mehmet-
dc.contributor.authorHabtemariam, Solomon-
dc.contributor.authorSharifi-Rad, Javad-
dc.date.accessioned2024-07-28T17:16:02Z-
dc.date.available2024-07-28T17:16:02Z-
dc.date.issued2024-
dc.identifier.issn1573-4129-
dc.identifier.issn1875-676X-
dc.identifier.urihttps://doi.org/10.2174/0115734129293569240327093703-
dc.identifier.urihttps://hdl.handle.net/11499/57571-
dc.description.abstractBackground: Salvia species known as Sage are among the important aromatic plants used in the world. This study, it was investigated the antioxidant capacity of Salvia cadmica and to investigate its protective effect on oxidative damage in t-BHP-induced fibroblast cells. Methods: Antioxidant activity and phenolic characterization of the extract were evaluated using DPPH, TPC, TFC, FRAP, and HPLC, respectively. TAS, TOS, MDA and 8-oxo-guanine, CAT, SOD, and GPx values were examined using enzyme-linked immunosorbent assay (ELISA). The antiproliferative and apoptosis effects of Salvia cadmica ethanolic extract were determined using XTT assay and fluorescent probes in fibroblast cells. Results: As a result of GC-MS analysis of Salvia cadmica ethanolic extract, carvacrol content was found to be high. The IC(50 )value of the DPPH antioxidant assay of the Salvia cadmica ethanolic extract was 80 +/- 0.51 mu g/mL. TPC, TFC, and FRAP values were found to be 18.25 +/- 0.64 (mg gallic acid/g powder), 1.691 +/- 0.314 (mg quercetin /g powder), 31.5 +/- 0.10 (mg Trolox/g powder), respectively. Total antioxidant and TOS values were found to be 0.383 +/- 0.033 (mmol Trolox Equ L-1), 16.31 +/- 0.71 (mu mol H2O2 L-1) for 0.25 mg/mL, and 0.725 +/- 0.05 (mmol Trolox Equ L-1), 12.02 +/- 0.56 (mu mol H2O2 L-1) for 0.5 mg/mL. In addition, while CAT and GPx significantly decreased enzyme activities, no significant change was observed in SOD enzyme activity. Ethanolic Salvia cadmica extract exhibited apoptotic features compared to only the t-BHP group. Conclusion: These results suggest that Slavica cadmica extract works through a free radical mechanism.en_US
dc.description.sponsorshipCUBAP [ECZ-29]en_US
dc.description.sponsorshipThis study was supported by CUBAP project no. ECZ-29.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Pharmaceutical Analysisen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSalvia cadmicaen_US
dc.subjectSODen_US
dc.subjectCATen_US
dc.subjectGPxen_US
dc.subject8-oxoguanidineen_US
dc.subjectphytochemicalsen_US
dc.subjectIn-Vitro Antioxidanten_US
dc.subjectLipid-Peroxidationen_US
dc.subjectEssential Oilen_US
dc.subjectExtractsen_US
dc.subjectWomenen_US
dc.titleProtective Effect of Salvia cadmica on Fibroblast Cells from t-bhp-induced Oxidative Damageen_US
dc.typeArticleen_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.startpage178en_US
dc.identifier.endpage187en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.2174/0115734129293569240327093703-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid27367980800-
dc.authorscopusid56659361500-
dc.authorscopusid35301914600-
dc.authorscopusid57196216016-
dc.authorscopusid56022647300-
dc.identifier.scopus2-s2.0-85196266115en_US
dc.identifier.wosWOS:001251801300001en_US
dc.institutionauthor-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.dept17.05. Molecular Biology and Genetics-
Appears in Collections:Fen Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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