Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57582
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dc.contributor.authorKaradurmuş, Nuri-
dc.contributor.authorKaplan, Muhammet Ali-
dc.contributor.authorSendur, Mehmet Ali Nahit-
dc.contributor.authorÜrün, Yüksel-
dc.contributor.authorDemirci, Umut-
dc.contributor.authorBurçak Karaca, Şaziye-
dc.contributor.authorGöktaş Aydın, Sabin-
dc.contributor.authorAykan, Musa Baris-
dc.contributor.authorBilici, Ahmet-
dc.contributor.authorSezer, Ahmet-
dc.contributor.authorYilmaz, Ulku-
dc.contributor.authorAbali, Huseyin-
dc.contributor.authorYumuk, Perran Fulden-
dc.contributor.authorDegirmencioglu, Serkan-
dc.contributor.authorDemirkazik, Ahmet-
dc.contributor.authorPaydas, Semra-
dc.contributor.authorMirili, Cem-
dc.contributor.authorTurna, Hande-
dc.contributor.authorKargi, Aysegul-
dc.contributor.authorOzdogan, Mustafa-
dc.contributor.authorGuven, Deniz Can-
dc.contributor.authorOzguroglu, Mustafa-
dc.contributor.authorKilickap, Saadettin-
dc.date.accessioned2024-07-28T17:16:04Z-
dc.date.available2024-07-28T17:16:04Z-
dc.date.issued2024-
dc.identifier.issn0300-7995-
dc.identifier.issn1473-4877-
dc.identifier.urihttps://doi.org/10.1080/03007995.2024.2359026-
dc.identifier.urihttps://hdl.handle.net/11499/57582-
dc.description.abstractObjectiveTo evaluate the efficacy and safety of nivolumab in the second-line (2L) or later-line (LL) treatment of patients with locally advanced/metastatic non-small cell lung cancer (NSCLC) in real-life setting in T & uuml;rkiye.MethodsThis study was designed as a national, multi-center, retrospective study. The study population was evaluated in two groups for the line of nivolumab therapy: those receiving nivolumab in the 2L (Group 2L) and third-line (3L) or LL (Group 3L/LL). Efficacy was evaluated based on one-year overall survival (OS) and progression-free survival (PFS). Safety was evaluated based on treatment-related adverse events (AEs) and nivolumab discontinuation rate.ResultsOf 244 patients, 52.9% were in Group 2L and 47.1% were in Group 3L/LL. Demographic and clinical characteristics did not differ between the groups. In Group 2L and Group 3L/LL, one-year OS and PFS rates were 60.8% and 61.4% (p = 0.592) and 31.2% and 21.3% (p = 0.078), respectively. The objective response rate (ORR) was 34.7% in Group 2L and 27.3% in Group 3L/LL (p = 0.262). The percentage of patients reporting at least one AE in Groups 2L and 3L/LL was 34.9% and 43.5%, respectively (p = 0.169). Fatigue was the most common (16.4%) treatment-related AE in each group. The groups were comparable regarding the AE frequency. Nivolumab was discontinued in 61 patients in Group 2L and 53 patients in Group 3L/LL, with the most common reason being disease progression (57.4% and 66.0%, respectively).ConclusionNivolumab is safe and effective in the 2L or 3L/LL treatment of locally advanced/metastatic NSCLC and associated with acceptable AEs in real-life setting. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer (around 85% of all lung cancers). Patients with NSCLC are usually diagnosed at advanced or metastatic stages. When cancer cells spread to other areas from where they first formed, it is called metastatic cancer. Surgery may not be a treatment option for such patients. Currently, immunotherapeutic agents are used in the treatment of NSCLC. Nivolumab is one of the approved immunotherapeutic agents in the treatment of patients with metastatic NSCLC, who have failed after receiving chemotherapy. Our study explored the efficacy and safety of nivolumab in real-life setting in T & uuml;rkiye. Nivolumab effectiveness was evaluated by overall survival (OS) and progression-free survival (PFS) rates. OS indicates the proportion of patients who are still alive at a given time after diagnosis or treatment initiation. PFS refers to the length of time during and after cancer treatment that a person lives with the disease but does not get worse. In the present study, one-year OS for 244 patients who received nivolumab was 61.1% and one-year PFS was 26.4%. Nivolumab safety was evaluated based on the frequency of adverse events observed during nivolumab therapy. Of the patients 38.9% had at least one side effect, with fatigue being the most common (16.4%). Our results support the earlier studies and showed that nivolumab was a safe and effective agent and is associated with acceptable side effects.en_US
dc.description.sponsorshipBMS Turkiyeen_US
dc.description.sponsorshipThis study was supported by BMS Turkiyeen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCurrent Medical Research and Opinionen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNivolumaben_US
dc.subjectnon-small cell lung canceren_US
dc.subjectsecond-line therapyen_US
dc.subjectefficacyen_US
dc.subjectsafetyen_US
dc.subjectReal-World Dataen_US
dc.subjectDocetaxelen_US
dc.titleEvaluation of the efficacy and safety of nivolumab in the second- or later-line treatment of patients with locally advanced/metastatic non-small cell lung cancer in Türkiye: a retrospective multicenter non-interventional registry studyen_US
dc.typeArticleen_US
dc.typeArticle; Early Accessen_US
dc.departmentPamukkale Universityen_US
dc.authoridGoktasAydin, Sabin/0000-0002-0077-6971;-
dc.identifier.doi10.1080/03007995.2024.2359026-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid23567989600-
dc.authorscopusid55504930000-
dc.authorscopusid57219456490-
dc.authorscopusid11540730500-
dc.authorscopusid26026850900-
dc.authorscopusid58629092200-
dc.authorscopusid57219414080-
dc.authorwosidGoktasAydin, Sabin/JAC-0864-2023-
dc.authorwosidAykan, Musa Baris/AEK-4253-2022-
dc.identifier.pmid38809230en_US
dc.identifier.scopus2-s2.0-85196674989en_US
dc.identifier.wosWOS:001261713400001en_US
dc.institutionauthor-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArticle-
item.openairetypeArticle; Early Access-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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