Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57584
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dc.contributor.authorCam, Dilaycan-
dc.contributor.authorÇakır, Cansel-
dc.contributor.authorKaraman, Ayse Hale-
dc.contributor.authorAbdelsalam, Amine Hafis-
dc.contributor.authorSıcak, Yusuf-
dc.contributor.authorAkata, Ilgaz-
dc.contributor.authorArslan, Şevki-
dc.contributor.authorÖztürk, Mehmet-
dc.date.accessioned2024-07-28T17:16:04Z-
dc.date.available2024-07-28T17:16:04Z-
dc.date.issued2024-
dc.identifier.issn0003-2719-
dc.identifier.issn1532-236X-
dc.identifier.urihttps://doi.org/10.1080/00032719.2024.2372670-
dc.identifier.urihttps://hdl.handle.net/11499/57584-
dc.description.abstractThe cytotoxic activities of apolar extract of Lactarius salmonicolor and its fractions and subfractions were screened against colon (CaCo-2), prostate (LNCaP), lung (H1299), and breast (MCF-7) cancerous cell lines. The main extract of Lactarius salmonicolor that was cytotoxic to CaCo-2 (EC50: 137.1 +/- 2.7 mu g/mL) and LNCap (EC50: 131.2 +/- 2.6 mu g/mL) mainly contains fatty acids (99.9%). To characterize the cytotoxic activity, it was fractionated by a silica gel column. Two cytotoxic fractions were re-fractionated to obtain subfractions. The extract, four cytotoxic fractions, and all subfractions were analyzed by gas chromatography-mass spectrometry (GC-MS). The GC-MS data and the cytotoxic activity (EC50) results were classified using principal component analyses (PCA). According to PCA, the cytotoxic fractions containing abundant benzoic acid (0.01%-0.35%), cinnamic acid (0.01%-0.36%), azelaic acid (0.01%-0.92%), 2,4-decadienal (0.01%-0.12%), (Z)-9-palmitoleic acid (0.01%-1.09%), 18-hydroxy 2,4-diene oleic acid (0.01%-26.71%), arachidic acid (0.01%-6.70%), desmosterol (0.01%-12.27%), and steroids (0.01%-9.51%) were clustered. LSP.9-10, which causes another cluster, is caused by 8,11,14- eicosatrienoic acid, 11,14,17-eicosatrienoic acid, 9(Z)-decenoic acid compounds, and saturated fatty acids with 10 and 16 carbons. Hence, these compounds may be responsible for the cytotoxic activity. This study demonstrates that GC-MS and chemometric analysis can identify the components responsible for biological activity in combination with biological activity data.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK 1001-121Z551]en_US
dc.description.sponsorshipThis study is part of D.C .'s Master's thesis and was supported by The Scientific and Technological Research Council of Turkey by project number TUBITAK 1001-121Z551 (Turkiye Bilimsel ve Teknolojik Arastirma Kurumu). DAS:Data will be made available upon request.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofAnalytical Lettersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxic activityen_US
dc.subjectedible mushroomsen_US
dc.subjectfatty acidsen_US
dc.subjectgas chromatography-mass spectrometry (GC-MS)en_US
dc.subjectLactarius salmonicoloren_US
dc.subjectprincipal component analysis (PCA)en_US
dc.subjectsteroidsen_US
dc.subjectUrinary Organic-Acidsen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectWild Mushroomsen_US
dc.subjectAntioxidant Propertiesen_US
dc.subjectCell-Growthen_US
dc.subjectDerivativesen_US
dc.subjectSteroidsen_US
dc.subjectRufusen_US
dc.titleCharacterization of the Cytotoxic Compounds of Lactarius salmonicolor R. Heim and Leclair by Gas Chromatography-Mass Spectrometry and Chemometricsen_US
dc.typeArticleen_US
dc.typeArticle; Early Accessen_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1080/00032719.2024.2372670-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid58193932600-
dc.authorscopusid55990068000-
dc.authorscopusid59208556300-
dc.authorscopusid57285719100-
dc.authorscopusid57189295279-
dc.authorscopusid26324773200-
dc.authorscopusid8684142100-
dc.identifier.scopus2-s2.0-85197757262en_US
dc.identifier.wosWOS:001266843100001en_US
dc.institutionauthor-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairetypeArticle; Early Access-
crisitem.author.dept17.02. Biology-
crisitem.author.dept29.07. Medical Services and Techniques-
Appears in Collections:Fen Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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