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https://hdl.handle.net/11499/57584
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DC Field | Value | Language |
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dc.contributor.author | Cam, Dilaycan | - |
dc.contributor.author | Çakır, Cansel | - |
dc.contributor.author | Karaman, Ayse Hale | - |
dc.contributor.author | Abdelsalam, Amine Hafis | - |
dc.contributor.author | Sıcak, Yusuf | - |
dc.contributor.author | Akata, Ilgaz | - |
dc.contributor.author | Arslan, Şevki | - |
dc.contributor.author | Öztürk, Mehmet | - |
dc.date.accessioned | 2024-07-28T17:16:04Z | - |
dc.date.available | 2024-07-28T17:16:04Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 0003-2719 | - |
dc.identifier.issn | 1532-236X | - |
dc.identifier.uri | https://doi.org/10.1080/00032719.2024.2372670 | - |
dc.identifier.uri | https://hdl.handle.net/11499/57584 | - |
dc.description.abstract | The cytotoxic activities of apolar extract of Lactarius salmonicolor and its fractions and subfractions were screened against colon (CaCo-2), prostate (LNCaP), lung (H1299), and breast (MCF-7) cancerous cell lines. The main extract of Lactarius salmonicolor that was cytotoxic to CaCo-2 (EC50: 137.1 +/- 2.7 mu g/mL) and LNCap (EC50: 131.2 +/- 2.6 mu g/mL) mainly contains fatty acids (99.9%). To characterize the cytotoxic activity, it was fractionated by a silica gel column. Two cytotoxic fractions were re-fractionated to obtain subfractions. The extract, four cytotoxic fractions, and all subfractions were analyzed by gas chromatography-mass spectrometry (GC-MS). The GC-MS data and the cytotoxic activity (EC50) results were classified using principal component analyses (PCA). According to PCA, the cytotoxic fractions containing abundant benzoic acid (0.01%-0.35%), cinnamic acid (0.01%-0.36%), azelaic acid (0.01%-0.92%), 2,4-decadienal (0.01%-0.12%), (Z)-9-palmitoleic acid (0.01%-1.09%), 18-hydroxy 2,4-diene oleic acid (0.01%-26.71%), arachidic acid (0.01%-6.70%), desmosterol (0.01%-12.27%), and steroids (0.01%-9.51%) were clustered. LSP.9-10, which causes another cluster, is caused by 8,11,14- eicosatrienoic acid, 11,14,17-eicosatrienoic acid, 9(Z)-decenoic acid compounds, and saturated fatty acids with 10 and 16 carbons. Hence, these compounds may be responsible for the cytotoxic activity. This study demonstrates that GC-MS and chemometric analysis can identify the components responsible for biological activity in combination with biological activity data. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey [TUBITAK 1001-121Z551] | en_US |
dc.description.sponsorship | This study is part of D.C .'s Master's thesis and was supported by The Scientific and Technological Research Council of Turkey by project number TUBITAK 1001-121Z551 (Turkiye Bilimsel ve Teknolojik Arastirma Kurumu). DAS:Data will be made available upon request. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Inc | en_US |
dc.relation.ispartof | Analytical Letters | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | edible mushrooms | en_US |
dc.subject | fatty acids | en_US |
dc.subject | gas chromatography-mass spectrometry (GC-MS) | en_US |
dc.subject | Lactarius salmonicolor | en_US |
dc.subject | principal component analysis (PCA) | en_US |
dc.subject | steroids | en_US |
dc.subject | Urinary Organic-Acids | en_US |
dc.subject | Antimicrobial Activity | en_US |
dc.subject | Wild Mushrooms | en_US |
dc.subject | Antioxidant Properties | en_US |
dc.subject | Cell-Growth | en_US |
dc.subject | Derivatives | en_US |
dc.subject | Steroids | en_US |
dc.subject | Rufus | en_US |
dc.title | Characterization of the Cytotoxic Compounds of Lactarius salmonicolor R. Heim and Leclair by Gas Chromatography-Mass Spectrometry and Chemometrics | en_US |
dc.type | Article | en_US |
dc.type | Article; Early Access | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1080/00032719.2024.2372670 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 58193932600 | - |
dc.authorscopusid | 55990068000 | - |
dc.authorscopusid | 59208556300 | - |
dc.authorscopusid | 57285719100 | - |
dc.authorscopusid | 57189295279 | - |
dc.authorscopusid | 26324773200 | - |
dc.authorscopusid | 8684142100 | - |
dc.identifier.scopus | 2-s2.0-85197757262 | en_US |
dc.identifier.wos | WOS:001266843100001 | en_US |
dc.institutionauthor | … | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.openairetype | Article; Early Access | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | 17.02. Biology | - |
crisitem.author.dept | 29.07. Medical Services and Techniques | - |
Appears in Collections: | Fen Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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