Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57586
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dc.contributor.authorKütük, Meryem Özlem-
dc.contributor.authorTufan, Ali Evren-
dc.contributor.authorKılıçaslan, Fethiye-
dc.contributor.authorGökcen, Cem-
dc.contributor.authorAksu, Gülen Güler-
dc.contributor.authorYektaş, Çiğdem-
dc.contributor.authorKandemir, Hasan-
dc.contributor.authorCelik, Fatma-
dc.contributor.authorMutluer, Tuba-
dc.contributor.authorBuber, Ahmet-
dc.contributor.authorKaradag, Mehmet-
dc.contributor.authorCoban, Nurdan-
dc.contributor.authorCoskun, Seyma-
dc.contributor.authorHangul, Zehra-
dc.contributor.authorAltintas, Ebru-
dc.contributor.authorAcikbas, Ufuk-
dc.contributor.authorGiray, Asli-
dc.contributor.authorAka, Yeliz-
dc.contributor.authorBasturk, Bilkay-
dc.contributor.authorKutuk, Ozgur-
dc.date.accessioned2024-07-28T17:16:05Z-
dc.date.available2024-07-28T17:16:05Z-
dc.date.issued2024-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://doi.org/10.1038/s41598-024-62121-z-
dc.identifier.urihttps://hdl.handle.net/11499/57586-
dc.description.abstractThe etiology of tic disorders (TDs) is not precisely known, although several lines of evidence suggest involvement of the immune system in pathogenesis. Here, we aimed to determine the expression levels of pro-inflammatory and anti-inflammatory cytokines in children with TD and compare them with those of healthy controls. Furthermore, we also evaluated their association with clinical variables in the TD group. Within the study period, 88 children with tic disorders and 111 healthy control children were enrolled. Most children with tic disorders were diagnosed with Tourette's disorder (n = 47, 53.4%) or persistent motor tic disorder (n = 39, 44.3%), while the remainder (n = 2, 2.3%) were diagnosed with persistent vocal tic disorder. We found that children with tic disorders had significantly elevated levels of IL-1 beta, TNF-alpha, IL-6 and IL-4 expression, while we detected lower expression levels of IL-17 in children with tic disorders. Our findings provide a molecular landscape of cytokine expression in children with TD, which may suggest a proinflammatory state not affected by the presence of comorbidity and symptom severity. Delineating the contribution of alterations in the immune system to the pathogenesis of tic disorders may pave the way for better therapeutic interventions.en_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTic disordersen_US
dc.subjectCytokinesen_US
dc.subjectImmune systemen_US
dc.subjectInflammationen_US
dc.subjectTourette syndromeen_US
dc.subjectNecrosis-Factor-Alphaen_US
dc.subjectDopamineen_US
dc.subjectInflammationen_US
dc.subjectInventoryen_US
dc.subjectScaleen_US
dc.titleCytokine expression profiles in children and adolescents with tic disordersen_US
dc.typeArticleen_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1038/s41598-024-62121-z-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid36246352500-
dc.authorscopusid14627787400-
dc.authorscopusid56779866800-
dc.authorscopusid36186815300-
dc.authorscopusid57207685361-
dc.authorscopusid37116339600-
dc.authorscopusid12800781300-
dc.identifier.pmid38956051en_US
dc.identifier.scopus2-s2.0-85197633737en_US
dc.identifier.wosWOS:001262145700138en_US
dc.institutionauthor-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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