Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57594
Title: Cytotoxic and Apoptosis-Inducing Activities of Iridium Complexes Bearing 2-Phenylimidazo[4,5-f][1,10]-Phenanthroline Derivatives in Human Cancer Cells
Authors: Mutlu, Dogukan
İpek, Cengiz
Sahin, Ç
Arslan, Şevki
Keywords: iridium complexes
2-phenylimidazo[4,5-f][1,10]-phenanthroline
cytotoxicity
apoptosis
mRNA expression
Anticancer
Efficacy
Publisher: Springer
Abstract: In recent years, there has been growing exploration of organometallic transition metal complexes as promising options for developing anticancer agents that offer the potential of reduced toxicity compared with the commonly utilized cisplatin analogs. In this respect, iridium complexes containing 2-phenylimidazo- [4,5-f][1,10]-phenanthroline derivatives with different substituents were investigated in different cell lines as potential anticancer agents. All the compounds exhibited potent cytotoxic activity against Caco-2, HeLa, A549, and MDA-MB-231 cell lines. EC50 values of compound 1 were found to be 6.44 mu M for Caco-2, 24.78 mu M for HeLa, 9.14 mu M for A549, and 4.45 mu M for the MDA-MB-231 cell line. Similarly, EC50 of 3 was found at 15.07, 14.15, 10.33, and 4.48 mu M respectively. The EC50 value of 2 was found to be 12.71 mu M for Caco-2, 24.31 mu M for HeLa, and 7.44 mu M for MDA-MB-231 cells. EC50 values of compound 4 were found to be 28.20 mu M for Caco-2, 12.79 mu M for HeLa, 8.33 mu M for A549, and 3.76 mu M for the MDA-MB-231 cell line. The results of gene expression and flow-cytometry analysis showed that the compounds caused the induction of apoptosis in all cancer cell lines by changing caspase 3, Bcl-2, and Bax proteins. The obtained results demonstrate that compounds could be introduced as potent agents to prevent the progression of certain types of cancer. However, preclinical and clinical trials will be needed to evaluate these complexes to obtain safe, effective, and optimal therapeutic drugs for cancer patients.
URI: https://doi.org/10.1007/s11094-024-03139-5
https://hdl.handle.net/11499/57594
ISSN: 0091-150X
1573-9031
Appears in Collections:Fen Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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