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Title: | Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study | Authors: | Sonmez, Hafize Emine Batu, Ezgi Deniz Isguder, Rana Sahin, Nihal Aliyev, Emil Aslan, Esma Coban, Suemeyra Güngörer, Vildan Karadağ, Şerife Gül Karaçayır, Nihal Kısaoğlu, Hakan Yekedüz Bülbül, Aydan Garip, Sevinç Karalı, Yasin Ayduran, Semra Demir, Selcan Kaya Akça, Ümmüşen Başaran, Özge Şahin, Sezgin Kasap, Belde Kilic, Sara Sebnem Kışla Ekinci, Rabia Miray Kısaarslan, Ayşenur Paç Kalyoncu, Mukaddes Bakkaloğlu, Sevcan Yüksel, Selçuk Aktay Ayaz, Nuray Çelikel Acar, Banu Sözeri, Betül Kasapçopur, Özgür Ünsal, Erbil Özen, Seza |
Keywords: | Systemic lupus erythematosus gastrointestinal system child autoimmune hepatitis Clinics American-College Damage Index Adult-Onset Features |
Publisher: | Sage Publications Ltd | Abstract: | Objective Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE.Methods The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology. All participants met the Systemic Lupus International Collaborating Clinics criteria.Results Out of 123 patients, 78 (63.4%) exhibited GIS involvement at the initial SLE diagnosis, whereas the remaining 45 (36.6%) developed GI symptoms after a median duration of 12 (3-140) months. Eighty-two (66.7%) individuals experienced symptoms related to the GI tract, whereas the remaining patients received a diagnosis of GI involvement through laboratory assessments. The predominant initial GIS involvement symptom was abdominal pain, observed in 77 (62.6%) patients, followed by elevated hepatic transaminases in 70 (56.9%), hepatomegaly in 40 (32.5%), diarrhea in 26 (21.1%), and jaundice in 11 (8.9%) patients. The GIS involvement was associated with SLE in 82 (78.6%), while it resulted from drug-related adverse events in 35 (28.5%) patients or comorbidities in 6 (0.5%) patients.Conclusion GIS involvement should be considered in all childhood onset-SLE patients, especially in the presence of suggestive symptoms or elevated hepatic transaminases. It is also crucial to consider SLE in the differential diagnosis of GIS manifestations in children. Apart from GIS involvement directly associated with SLE, adverse events of drugs should be kept in mind. | URI: | https://doi.org/10.1177/09612033241279071 https://hdl.handle.net/11499/57898 |
ISSN: | 0961-2033 1477-0962 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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