Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57935
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dc.contributor.authorMert, M.-
dc.contributor.authorDinç, U.-
dc.contributor.authorÇeri, M.-
dc.contributor.authorDursun, B.-
dc.contributor.authorÖzban, M.-
dc.contributor.authorAslan, H.S.-
dc.contributor.authorAvcı, E.-
dc.contributor.authorOdabaşı, Şevki Yetkin-
dc.date.accessioned2024-09-30T15:27:01Z-
dc.date.available2024-09-30T15:27:01Z-
dc.date.issued2024-
dc.identifier.issn1304-0855-
dc.identifier.urihttps://doi.org/10.6002/ect.2023.0315-
dc.identifier.urihttps://hdl.handle.net/11499/57935-
dc.description.abstractObjectives: This study investigated whether kidney transplant donors experience increased arterial stiffness compared with the general population and how arterial stiffness changes over time. Materials and Methods: Our study included 59 kidney transplant donors and 27 healthy volunteers. All subjects underwent cardio-ankle vascular index measurements. We studied fibroblast growth factor-23, klotho, monocyte chemoattractant protein-1, N-terminal pro-B-type natriuretic peptide, indoxyl sulfate, and p-cresyl sulfate levels. Results: Cardio-ankle vascular index level was higher in donors 6 to 11 years after donation (8.02 ± 0.24 m/s) than in donors 2 to 6 years after donation (7.02 ± 0.27 m/s) and healthy volunteers (6.65 ± 0.22 m/s). Cardio-ankle vascular index level was positively correlated with age (r = 0.382, P < .001) and levels of triglyceride (r = 0.213, P = .049), blood urea nitrogen (r = 0.263, P = .014), creatinine (r = 0.354, P = .001), calcium (r = 0.228, P = .035), indoxyl sulfate (r = 0.219, P = .042), p-cresyl sulfate (r = 0.676, P ≤ .001), and monocyte chemoattractant protein-1 (r = 0.451, P ≤ .001) and negatively correlated with estimated glomerular filtration rate (r =-0.383, P <.001). Multiple linear regression analysis revealed that age (P = .026, B = 0.244), mean arterial blood pressure (P < .001, B = 0.446), blood urea nitrogen (P = .006, B = 0.302), creatinine (P = .032, B = 0.236), estimated glomerular filtration rate (P = .003, B =-0.323), fibroblast growth factor-23 (P = .007, B = 0.294), N-terminal pro-B-type natriuretic peptide (P = .005, B = 0.304), and monocyte chemoattractant protein-1 (P ≤ .001, B = 0.434) independently predicted cardio-ankle vascular index levels. Conclusions: Even without additional risk factors, kidney donors should be followed closely for arterial stiffness and cardiovascular disease, especially in the long-term (>5 years) after kidney transplant. © Başkent University 2024.en_US
dc.description.sponsorshipPamukkale University Medical School; Akdeniz Üniversitesi; Gizem Sultan Açıkgöz Mert; 6Department of Measurement and Evaluation; Pamukkale Üniversitesi, PAÜ, (2022TAP001); Pamukkale Üniversitesi, PAÜen_US
dc.language.isoenen_US
dc.publisherBaskent Universityen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial stiffnessen_US
dc.subjectCAVIen_US
dc.subjectKidney donorsen_US
dc.subjectMonocyte chemoattractant protein-1en_US
dc.subjectUremic toxinsen_US
dc.subjectAdulten_US
dc.subjectBiomarkersen_US
dc.subjectCardio Ankle Vascular Indexen_US
dc.subjectCase-Control Studiesen_US
dc.subjectChemokine CCL2en_US
dc.subjectFemaleen_US
dc.subjectFibroblast Growth Factor-23en_US
dc.subjectFibroblast Growth Factorsen_US
dc.subjectHumansen_US
dc.subjectIndicanen_US
dc.subjectInflammation Mediatorsen_US
dc.subjectKidney Transplantationen_US
dc.subjectLiving Donorsen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPredictive Value of Testsen_US
dc.subjectRisk Factorsen_US
dc.subjectTime Factorsen_US
dc.subjectTreatment Outcomeen_US
dc.subjectUremiaen_US
dc.subjectVascular Calcificationen_US
dc.subjectVascular Stiffnessen_US
dc.subjectautacoiden_US
dc.subjectbiological markeren_US
dc.subjectCCL2 protein, humanen_US
dc.subjectfibroblast growth factoren_US
dc.subjectfibroblast growth factor 23en_US
dc.subjectindicanen_US
dc.subjectmonocyte chemotactic protein 1en_US
dc.subjectadulten_US
dc.subjectadverse eventen_US
dc.subjectarterial stiffnessen_US
dc.subjectblooden_US
dc.subjectblood vessel calcificationen_US
dc.subjectcardio-ankle vascular indexen_US
dc.subjectcase control studyen_US
dc.subjectdiagnosisen_US
dc.subjectetiologyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectkidney transplantationen_US
dc.subjectliving donoren_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectpathophysiologyen_US
dc.subjectpredictive valueen_US
dc.subjectrisk factoren_US
dc.subjecttime factoren_US
dc.subjecttreatment outcomeen_US
dc.subjecturemiaen_US
dc.titleRelationship Between Arterial Stiffness, Measured by Cardio-Ankle Vascular Index, and Uremic Toxins, Vascular Calcification, and Inflammation Markers After Kidney Donationen_US
dc.typeArticleen_US
dc.identifier.volume22en_US
dc.identifier.issue8en_US
dc.identifier.startpage613en_US
dc.identifier.endpage621en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.6002/ect.2023.0315-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57211980632-
dc.authorscopusid57201185707-
dc.authorscopusid23988330000-
dc.authorscopusid6506969339-
dc.authorscopusid12446217300-
dc.authorscopusid57226492427-
dc.authorscopusid57209468091-
dc.identifier.pmid39254073en_US
dc.identifier.scopus2-s2.0-85203781874en_US
dc.identifier.wosWOS:001335289400004en_US
dc.institutionauthor-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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