Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/57974
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dc.contributor.authorSargın, Fatih-
dc.contributor.authorSargın, Zeynep Gök-
dc.contributor.authorSungurtekin, Hülya-
dc.date.accessioned2024-09-30T15:27:07Z-
dc.date.available2024-09-30T15:27:07Z-
dc.date.issued2024-
dc.identifier.issn2630-5720-
dc.identifier.urihttps://doi.org/10.14744/hnhj.2022.98360-
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263367-
dc.identifier.urihttps://hdl.handle.net/11499/57974-
dc.description.abstractIntroduction: In coronavirus disease 2019 (COVID-19), liver injury has been associated with the direct cytopathic effect on cholangiocytes, an uncontrolled immune response, sepsis, or drug-induced liver injury. This study aimed to evaluate liver damage in COVID-19 patients in the intensive care unit. Methods: Between January 1, 2021, and June 1, 2021, medications, mortality rates, length of stay in the intensive care unit, liver function tests, and acute phase reactants, during admission to the unit and on the 3 rd, 7th, and 15th days of follow-up were analyzed retrospectively. Results: A total of 92 patients were included in the study. In a mean follow-up of 2 weeks, ALT levels increased by 62%, AST levels increased by 78.3%, GGT levels increased by 65.2%, ALP levels increased by 43.5%, and total bilirubin levels increased by 20.7% of the patients were observed. In repeated measurements of the patients, significant increases were observed in ALP (p=0.013), GGT (p=0.001), and bilirubin levels (p=0.012). Thirty-six patients resulted in mortality, and in patients who died, AST (p=0.02), day 15 AST (p=0.02), GGT (p=0.02), and ALP (p=0.009) values were observed to be significantly high. There was no relationship between CRP and IL-6 levels, transaminases, and cholestasis enzymes. When the patients who received and did not receive favipiravir treatment were compared, there was no difference other than the 3rd day AST (p=0.043) value. Discussion and Conclusion: Increases in cholestasis enzymes were detected in the 15-day follow-up of patients admitted to the intensive care unit due to severe COVID-19. Furthermore, it was observed that the transaminase and cholestasis enzymes of the patients who ended in mortality were higher. In addition, liver enzymes were at similar levels between patients who received and did not receive favipiravir treatment.en_US
dc.language.isoenen_US
dc.relation.ispartofHaydarpaşa Numune Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of Liver Damage in COVID-19 Patients Followed in The Intensive Care Uniten_US
dc.typeArticleen_US
dc.identifier.volume64en_US
dc.identifier.issue1en_US
dc.identifier.startpage18en_US
dc.identifier.endpage23en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.14744/hnhj.2022.98360-
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.trdizinid1263367en_US
dc.institutionauthorSargın, Fatih-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
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