Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5803
Title: MRI measures of hippocampus in mild cognitive impairment and Alzheimer patients
Authors: Öncel, C.
Özdemir, B.
Erdogan, C.
Kiroglu, Y.
Şahiner, T.
Keywords: Alzheimer disease
Hippocampus
Magnetic resonance imaging
Mild cognitive impairment
article
brain atrophy
brain size
clinical article
cognition
comparative study
controlled study
hippocampus
human
mild cognitive impairment
mini mental state examination
neuroimaging
nuclear magnetic resonance imaging
Abstract: Objective: In this study, we aimed to compare the hippocampal volumes of patients diagnosed as Alzheimer's disease (AD) and mild cognitive impairment (MCI) and of healthy objects. We also tried to demonstrate whether there was a possible correlation between the cognitive tests and the hippocampal volumes. Materials and Methods: The mini mental state examination (MMSE), ADAS-Cog and Global Deterioration Scale (GDS) were administrated to the patients having AD (n= 20). MMSE and ADAS-Cog to MCI patients (n= 20) and the healthy control group (n= 18). Both right and left hippocampal volumes were measured by a three dimensioned Surf Driver programme with the support of cranial magnetic resonance imaging (MRI). Results: Both right and left hippocampal volumes of the AD group were significantly smaller than the MCI and the control groups. Bilateral hippocampal volumes of MCI group were also smaller than the control group (hippocampal volumes; AD < MCI < control groups). The differences between the right and the left hippocampal volumes were not significant in both AD or MCI groups. Conclusion: Surf Driver method successfully demonstrated the relative hippocampal atrophy in the AD and the MCI groups when compared with the healthy controls.
URI: https://hdl.handle.net/11499/5803
ISSN: 1301-062X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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