Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/58043
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dc.contributor.authorOzdemir, Melek-
dc.contributor.authorDogu, Gamze Gokoz-
dc.contributor.authorTaskoylu, Burcu Yapar-
dc.contributor.authorDemiray, Atike Gökçen-
dc.contributor.authorÇakan Demirel, Burçin-
dc.contributor.authorDoğan, Tolga-
dc.contributor.authorGüçlü Kantar, Taliha-
dc.contributor.authorYaren, Arzu-
dc.contributor.authorDegirmencioglu, Serkan-
dc.contributor.authorTas, Semra-
dc.contributor.authorYildiz, Bedriye Acikgoz-
dc.contributor.authorOzel, Gamze Serin-
dc.date.accessioned2024-10-20T16:20:47Z-
dc.date.available2024-10-20T16:20:47Z-
dc.date.issued2024-
dc.identifier.issn2587-0262-
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2024.93898-
dc.identifier.urihttps://hdl.handle.net/11499/58043-
dc.description.abstractAim According to the information obtained from the World Health Organization database, the incidence of hepatocellular carcinoma (HCC) in Turkey increased by 17.78% between the years of 2018 and 2020. In this study, we investigated the prognostic value of albumin-bilirubin (ALBI) score and lymphocyte-associated inflammation markers on overall survival (OS) and progression-free survival (PFS) in advanced hepatocellular carcinoma. Materials and Methods Data of 141 patients with advanced HCC were included in this study. ALBI score and lymphocyte-associated inflammatory marker were calculated. As a result, the prognostic significance of these tests for survival were evaluated. Results The median age was 65 years (min: 26-max: 88). There were 58 (41.1%) hepatitis B virus (HBV) positive, 20 (14.2%) hepatitis C (HCV) positive and 63 (44.7%) patients with no history of hepatitis. Cut-off values of ALBI score and lymphocyte-associated inflammation markers were found by receiver operating characteristic analysis. ALBI (p<0.001), aspartate aminotransferase-to-lymphocyte ratio (ALRI) (p<0.001), prognostic nutritional index (PNI) (p=0.030), hemoglobin, albumin, lymphocyte, and platelet score (HALP) (p=0.003) scores were significantly associated with survival. In multivariate analysis, being >= 65 years old [hazard ratios (HR): 2.13; 95% confidence interval (CI): 1.44-3.17; p<0.001], ALRI >= 30.79 (HR: 2.14; 95% CI: 1.20-3.82; p=0.009) predicted an increased risk of death and ALBI >=-2.54 (HR: 0.44, 95% CI: 0.29-0.69; p<0.001) predicted a decreased risk of death. Being >= 65 years old (HR: 174, 95% CI: 1.18-2.56; p=0.005) increased the risk of progression. Conclusion This study supports the statistically significant association of ALBI score and lymphocyte-associated inflammation markers (ALRI, PNI, HALP) with OS and PFS in advanced HCC patients. It is thought that this study will contribute to the literature and clinical practice.en_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofNamik Kemal Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHCCen_US
dc.subjectALBI scoreen_US
dc.subjectlymphocyte-associated inflammatory markeren_US
dc.subjectALRIen_US
dc.subjectsurvivalen_US
dc.subjectCanceren_US
dc.subjectCytokinesen_US
dc.titlePrognostic value of albi score and lymphocyte-associated inflammation markers in advanced hepatocellular carcinoma: a single centre retrospective cross-sectional studyen_US
dc.typeArticleen_US
dc.identifier.volume12en_US
dc.identifier.issue3en_US
dc.identifier.startpage155en_US
dc.identifier.endpage162en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.4274/nkmj.galenos.2024.93898-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.trdizinid1282776en_US
dc.identifier.wosWOS:001325743200002en_US
dc.institutionauthor-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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