Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/58072
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dc.contributor.authorErdem, Ahmet-
dc.contributor.authorMutlu, Doğukan-
dc.contributor.authorKilincarslan, R.-
dc.contributor.authorDayan, O.-
dc.contributor.authorArslan, Sevki-
dc.date.accessioned2024-10-20T16:20:52Z-
dc.date.available2024-10-20T16:20:52Z-
dc.date.issued2024-
dc.identifier.issn2069-5837-
dc.identifier.urihttps://doi.org/10.33263/BRIAC144.082-
dc.identifier.urihttps://hdl.handle.net/11499/58072-
dc.description.abstractIn this article, cytotoxic and apoptotic properties of previously synthesized and characterized four different half‐sandwich ruthenium (II) complexes (C1-C4) with 2-(2¢-quinoly) benzimidazole frameworks (L1-L5) were described. These Ru (II) complexes (C1-C4) had strong cytotoxic activity towards the human glioblastoma (U373) cancer cell line with low toxicity to the non-cancerous human embryonic kidney (HEK293) cell line. Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2. Our results indicate that ruthenium (II) complexes with 2-(2¢-quinoly) benzimidazole frameworks, especially C1 and C4, had a higher cytotoxic and apoptotic activity in human glioblastoma cells, and they should be further evaluated in detail for its anticancer properties as a new therapeutical strategy for glioblastoma. © 2024 by the authors.en_US
dc.language.isoenen_US
dc.publisherAMG Transcend Associationen_US
dc.relation.ispartofBiointerface Research in Applied Chemistryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-(2¢-quinoly)benzimidazoleen_US
dc.subjectanticanceren_US
dc.subjectglioblastomaen_US
dc.subjecthalf-sandwich Ru(II)en_US
dc.subjectpiano-stool complexen_US
dc.titleHalf-Sandwich Ru(II) Complexes Bearing 2-(2¢-quinoly)benzimidazoles with Anticancer Activityen_US
dc.typeArticleen_US
dc.identifier.volume14en_US
dc.identifier.issue4en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.33263/BRIAC144.082-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid7004459764-
dc.authorscopusid57212511655-
dc.authorscopusid16052784700-
dc.authorscopusid13805114500-
dc.authorscopusid8684142100-
dc.identifier.scopus2-s2.0-85204957010en_US
dc.institutionauthor…-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept01.04. Centre For Advanced Research Laboratory-
crisitem.author.dept17.01. Chemistry-
crisitem.author.dept17.02. Biology-
Appears in Collections:Fen Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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