Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/58122
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dc.contributor.authorTopsakal, Şenay-
dc.contributor.authorÖzmen, Özlem-
dc.date.accessioned2024-10-20T16:21:43Z-
dc.date.available2024-10-20T16:21:43Z-
dc.date.issued2024-
dc.identifier.issn1300-7416-
dc.identifier.urihttps://doi.org/10.17343/sdutfd.1456620-
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1266970-
dc.identifier.urihttps://hdl.handle.net/11499/58122-
dc.description.abstractObjective: Certain types of bacteria contain lipopolysaccharide (LPS), which can cause widespread inflammation in the body, including the pancreas. Fluvoxamine (FLV), a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for psychiatric disorders, has been shown to possess anti-inflammatory properties and may be beneficial in conditions involving tissue damage and inflammation. This study aims to evaluate the potential protective effects of FLV against experimentally induced pancreatic disease in rats using LPS. Material and Method: In this experiment, a total of 32 Wistar albino male rats were randomly divided into four groups: control, LPS (5 mg/kg, intraperitoneally (i.p.)), LPS + FLV (50 mg/kg FLV, i.p.) and FLV. The rats were euthanatized 6 hours after the administration of LPS, and serum and pancreas tissue samples were collected during the necropsy for biochemical, histopathological, and immunohistochemical evaluations. Results: According to the study findings, LPS lowered blood glucose levels. Histological examination showed that LPS caused edema, mild infiltration of inflammatory cells, increased vacuolization in the cells of the Langerhans islet, and severe hyperemia. Immunohistochemical investigations revealed a reduction in the expression of insulin and amylin. The biochemical, histopathological, and immunohistochemical outcomes were improved by FLV. Conclusion: The results of this experimental rat model study indicated that LPS causes damage to the endocrine pancreas. However, FLV demonstrated significant ameliorative effects on the pancreas in rats with LPS-induced pancreatitis.en_US
dc.language.isoenen_US
dc.relation.ispartofSüleyman Demirel Üniversitesi Tıp Fakültesi Dergisien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleFluvoxamine administration attenuates lipopolysaccharide-induced pancreatic damageen_US
dc.typeArticleen_US
dc.identifier.volume31en_US
dc.identifier.issue3en_US
dc.identifier.startpage221en_US
dc.identifier.endpage227en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.17343/sdutfd.1456620-
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.trdizinid1266970en_US
dc.institutionauthor-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
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