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https://hdl.handle.net/11499/58212
Title: | Green Synthesis of Electroactive Magnesium Ferrite Nanoparticles for the Selective Determination of Mefenamic Acid in Blood, Pharmaceutical Products, and Wastewater |
Authors: | Perveen, Saima Baig, Jameel Ahmed Sherazi, Syed Tufail Hussain Memon, Shahabuddin Akhtar, Khalil Hussain, Sajjad Abbasi, Fahad |
Keywords: | Blood analysis differential pulse voltammetry green synthesis mefenamic acid MgFe4O7-NPs Simultaneous Electrochemical Detection Nanostructures Sensor Metal |
Publisher: | Taylor & Francis Inc |
Abstract: | Mefenamic acid (MNA) treats sports injuries, rheumatoid arthritis, and osteoarthritis. However, improper use/disposal of MNA results in the accumulation of toxic metabolites that may serious disease. The purpose of this study is to fabricate a nano ferrite-based electrochemical sensor for robust, and sensitive determination of MNA. Magnesium ferrite nanoparticles (MgFe4O7-NPs) were synthesized using a green approach using a Mentha leaf extract. The analytical characterization of MgFe4O7-NPs displayed a hexagonal structure and a particle size of less than 21 nm with rough and porous morphology. The synthesized MgFe4O7-NPs were used to fabricate an electrochemical sensor by modifying a glassy carbon electrode (MgFe4O7-NPs/GCE). The cyclic voltammetry (CV) characterization of the electrode confirms excellent redox and diffusion control for electroactive species. Thus, the MgFe4O7-NPs/GCE was used to determine MNA by differential pulse voltammetry (DPV). The results showed a linear relationship between oxidation peak current and concentration of MNA from 10 x 10(-9) to 2.30 x 10(-4) M (R-2 = 0.9918) with a detection limit of 1.12 x 10(-9) M. The analytical performance of the fabricated sensor has been evaluated for MNA in blood samples, pharmaceutical tablets, and water samples with satisfactory results. |
URI: | https://doi.org/10.1080/00032719.2024.2413455 https://hdl.handle.net/11499/58212 |
ISSN: | 0003-2719 1532-236X |
Appears in Collections: | Fen Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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