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https://hdl.handle.net/11499/5845
Title: | Evaluation of deleted in malignant brain tumors 1 (DMBT1) gene expression in bladder carcinoma cases: Preliminary study | Authors: | Dodurga, Yavuz Avci, C.B. Yilmaz, S. Dogan, Z.O. Kesen, Z. Tataroglu, C. Satiroglu-Tufan, N.L. |
Keywords: | Bladder cancer DMBT1 gene gene expression real-time online RT-PCR messenger RNA adult aged article bladder carcinoma cancer grading cancer patient DBMT1 gene down regulation evaluation female gene expression regulation histopathology human human tissue major clinical study male oncogene reverse transcription polymerase chain reaction transitional cell carcinoma Adult Aged Aged, 80 and over Carcinoma, Transitional Cell Down-Regulation Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Grading Receptors, Cell Surface Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Urinary Bladder Neoplasms |
Abstract: | This study was undertaken to evaluate the expression of DMBT1 in bladder cancer and its correlation with clinico-pathological parameters analyzed in bladder carcinoma patients. We investigated DMBT1 in 56 paraffin embedded specimens of transitional cell carcinoma of the urinary bladder. We assessed DMBT1 gene expression at mRNA level by RT-PCR. Our results show 100% expression of DMBT1 in bladder carcinoma samples. Due to this preliminary results; gene expression was compared to tumor grade, and a significant difference was detected between grade 1 and 3 (p=0.028). The down-regulation of DMBT1 gene expression in carcinomas suggests the possible role in bladder cancer. © 2011 Informa UK, Ltd. | URI: | https://hdl.handle.net/11499/5845 https://doi.org/10.3109/1354750X.2011.620627 |
ISSN: | 1354-750X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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