Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5845
Title: Evaluation of deleted in malignant brain tumors 1 (DMBT1) gene expression in bladder carcinoma cases: Preliminary study
Authors: Dodurga, Yavuz
Avci, C.B.
Yilmaz, S.
Dogan, Z.O.
Kesen, Z.
Tataroglu, C.
Satiroglu-Tufan, N.L.
Keywords: Bladder cancer
DMBT1 gene
gene expression
real-time online RT-PCR
messenger RNA
adult
aged
article
bladder carcinoma
cancer grading
cancer patient
DBMT1 gene
down regulation
evaluation
female
gene expression regulation
histopathology
human
human tissue
major clinical study
male
oncogene
reverse transcription polymerase chain reaction
transitional cell carcinoma
Adult
Aged
Aged, 80 and over
Carcinoma, Transitional Cell
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Neoplasm Grading
Receptors, Cell Surface
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
Urinary Bladder Neoplasms
Abstract: This study was undertaken to evaluate the expression of DMBT1 in bladder cancer and its correlation with clinico-pathological parameters analyzed in bladder carcinoma patients. We investigated DMBT1 in 56 paraffin embedded specimens of transitional cell carcinoma of the urinary bladder. We assessed DMBT1 gene expression at mRNA level by RT-PCR. Our results show 100% expression of DMBT1 in bladder carcinoma samples. Due to this preliminary results; gene expression was compared to tumor grade, and a significant difference was detected between grade 1 and 3 (p=0.028). The down-regulation of DMBT1 gene expression in carcinomas suggests the possible role in bladder cancer. © 2011 Informa UK, Ltd.
URI: https://hdl.handle.net/11499/5845
https://doi.org/10.3109/1354750X.2011.620627
ISSN: 1354-750X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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