Synthesis and Characterization of Amido-Thiourea Based p-tert-butylcalix[4]arene Compound and Investigation of Transition Metal Complex Properties

Abstract

In host-guest complexes, the compatibility of the size and shape of the host cavity and the guest molecule is essential in the formation of the host-guest complex. Considered third-generation macrocyclic hosts, calixarenes attract the attention of researchers in supramolecular chemistry as they offer a wide range of applications in fields such as biocatalysis, enzyme analysis, pharmaceuticals, and biosensing. The synthesis of host molecules for anionic and cationic guest compounds has a very important place in coordination chemistry. Calixarenes are known as one of the important types of supramolecular compounds and are an important class of easily synthesized compounds that can act as a suitable receptors for cations, anions, and organic molecules. When calixarene compounds, which have an important place in host-guest chemistry, are derivatized appropriately, the coordination ability of the molecule against metal cations increases. These derivatizations gained importance due to the sensory properties of the molecule, and different studies were started considering that a larger cavity and functional group are required for more guest molecules. In this study, a new ligand of 1,3-disubstituted p-tert-butylcalix[4]arene derivative with increased donor atomic number with amide and thiourea groups in its structure was synthesized. Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized with the compound and the structures of the compounds were characterized by UV-vis, FT-IR, $^1H-NMR$, $^{13}C-NMR$, and mass spectrometry.