Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/5849
Title: | Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population | Authors: | Bulut, H. Pehlivan, M. Alper, S. Tomatır, Ayşe Gaye Onay, H. Yüksel, S.E. Özkinay, F. |
Keywords: | Melanocytes Oxidative stress catalase gene (CAT) PCR-RFLP Vitiligo catalase hydrogen peroxide Article CAT gene clinical article controlled study exon female gene frequency genetic association genetic polymorphism genetic susceptibility genotype human male polymerase chain reaction restriction fragment length polymorphism risk assessment Turk (people) vitiligo article ethnology genetic predisposition genetics metabolism middle aged single nucleotide polymorphism Turkey (republic) Catalase Exons Female Genetic Predisposition to Disease Genotype Humans Hydrogen Peroxide Male Middle Aged Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Turkey |
Publisher: | Fundacao de Pesquisas Cientificas de Ribeirao Preto | Abstract: | Accumulation of hydrogen peroxide (H2O2) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by PCR-RFLP. The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. We found no association between CAT (Asp-389) gene polymorphism and vitiligo susceptibility in Turkish vitiligo patients. © FUNPEC-RP. | URI: | https://hdl.handle.net/11499/5849 https://doi.org/10.4238/2011.October.31.12 |
ISSN: | 1676-5680 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
gmr1463.pdf | 384.53 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
14
checked on Jun 22, 2024
WEB OF SCIENCETM
Citations
13
checked on Sep 24, 2024
Page view(s)
70
checked on Aug 24, 2024
Download(s)
26
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.