Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5849
Title: Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population
Authors: Bulut, H.
Pehlivan, M.
Alper, S.
Tomatır, Ayşe Gaye
Onay, H.
Yüksel, S.E.
Özkinay, F.
Keywords: Melanocytes
Oxidative stress catalase gene (CAT)
PCR-RFLP
Vitiligo
catalase
hydrogen peroxide
Article
CAT gene
clinical article
controlled study
exon
female
gene frequency
genetic association
genetic polymorphism
genetic susceptibility
genotype
human
male
polymerase chain reaction
restriction fragment length polymorphism
risk assessment
Turk (people)
vitiligo
article
ethnology
genetic predisposition
genetics
metabolism
middle aged
single nucleotide polymorphism
Turkey (republic)
Catalase
Exons
Female
Genetic Predisposition to Disease
Genotype
Humans
Hydrogen Peroxide
Male
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Turkey
Publisher: Fundacao de Pesquisas Cientificas de Ribeirao Preto
Abstract: Accumulation of hydrogen peroxide (H2O2) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by PCR-RFLP. The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. We found no association between CAT (Asp-389) gene polymorphism and vitiligo susceptibility in Turkish vitiligo patients. © FUNPEC-RP.
URI: https://hdl.handle.net/11499/5849
https://doi.org/10.4238/2011.October.31.12
ISSN: 1676-5680
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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