Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/58709
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dc.contributor.authorDodurga, Y.-
dc.contributor.authorSeçme, M.-
dc.contributor.authorElmas, L.-
dc.contributor.authorDemirkıran, N.-
dc.contributor.authorSağ, S.-
dc.contributor.authorPala, U.-
dc.contributor.authorAkdağ, Z.-
dc.date.accessioned2025-01-22T17:15:43Z-
dc.date.available2025-01-22T17:15:43Z-
dc.date.issued2025-
dc.identifier.issn1309-9833-
dc.identifier.urihttps://doi.org/10.31362/patd.1552452-
dc.identifier.urihttps://hdl.handle.net/11499/58709-
dc.description.abstractPurpose: Leukemia is a type of cancer caused by the uncontrolled proliferation of blood cells. The purpose of this study was to investigate the effects of cisplatin (CIS), a chemotherapeutic agent used in the treatment of leukemia, on the Kasumi-1 leukemia cell line. Materials and methods: The study measured the effect of CIS on Kasumi-1 cells by calculating IC50 values for cell viability. The mRNA expression levels of apoptosis and cell cycle-related genes were then assessed using Real-Time PCR. In addition, the effects of CIS on DNA damage were investigated using the comet assay. Results: Significant changes in apoptosis and cell cycle-related genes were observed in CIS-treated groups. These included alterations in the mRNA levels of p53, BCL-2, CHECK 1, CDC25C, CDK 6, URG4/URGCP, GADD45A, CCND1, GADD45G, and ATM genes. Comet analysis confirmed CIS's effects on DNA damage. Conclusion: This study aimed to better understand how CIS affects genetic mechanisms in leukemia cells and provide new insights into leukemia treatment. The findings will help us better understand the role of CIS in leukemia treatment and will serve as a valuable reference for future research. © 2025, Pamukkale University. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherPamukkale Universityen_US
dc.relation.ispartofPamukkale Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectCisplatinen_US
dc.subjectDna Damageen_US
dc.subjectKasumi-1 Cellen_US
dc.subjectLeukemiaen_US
dc.titleImpact Of Cisplatin On Kasumi-1 Leukemia Cell Line: Gene Expression And Dna Damage;en_US
dc.title.alternativesisplatinin Kasumi-1 Lösemi Hücre Hattı Üzerindeki Etkisi: Gen Ekspresyonu ve Dna Hasarıen_US
dc.typeArticleen_US
dc.identifier.volume18en_US
dc.identifier.issue1en_US
dc.identifier.startpage63en_US
dc.identifier.endpage71en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.31362/patd.1552452-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid24066601700-
dc.authorscopusid56499294100-
dc.authorscopusid37114268300-
dc.authorscopusid58979419200-
dc.authorscopusid58126668800-
dc.authorscopusid59506570800-
dc.authorscopusid59506570800-
dc.identifier.scopus2-s2.0-85214525532-
dc.identifier.scopusqualityQ4-
dc.identifier.wosqualityN/A-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
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